Adult-born neurons from the dorsal, intermediate, and ventral regions of the longitudinal axis of the hippocampus exhibit differential sensitivity to glucocorticoids.

Autor: Levone BR; Department of Anatomy and Neuroscience, University College Cork, Cork, Ireland., Codagnone MG; Department of Anatomy and Neuroscience, University College Cork, Cork, Ireland.; APC Microbiome Ireland, University College Cork, Cork, Ireland., Moloney GM; Department of Anatomy and Neuroscience, University College Cork, Cork, Ireland.; APC Microbiome Ireland, University College Cork, Cork, Ireland., Nolan YM; Department of Anatomy and Neuroscience, University College Cork, Cork, Ireland.; APC Microbiome Ireland, University College Cork, Cork, Ireland., Cryan JF; Department of Anatomy and Neuroscience, University College Cork, Cork, Ireland.; APC Microbiome Ireland, University College Cork, Cork, Ireland., O' Leary OF; Department of Anatomy and Neuroscience, University College Cork, Cork, Ireland. o.oleary@ucc.ie.; APC Microbiome Ireland, University College Cork, Cork, Ireland. o.oleary@ucc.ie.
Jazyk: angličtina
Zdroj: Molecular psychiatry [Mol Psychiatry] 2021 Jul; Vol. 26 (7), pp. 3240-3252. Date of Electronic Publication: 2020 Jul 24.
DOI: 10.1038/s41380-020-0848-8
Abstrakt: Hippocampal neurogenesis has been shown to play roles in learning, memory, and stress responses. These diverse roles may be related to a functional segregation of the hippocampus along its longitudinal axis. Indeed, the dorsal hippocampus (dHi) plays a predominant role in spatial learning and memory, while the ventral hippocampus (vHi) is predominantly involved in the regulation of anxiety, a behaviour impacted by stress. Recent studies suggest that the area between them, the intermediate hippocampus (iHi) may also be functionally independent. In parallel, it has been reported that chronic stress reduces neurogenesis preferentially in the vHi rather the dHi. We thus aimed to determine whether such stress-induced changes in neurogenesis could be related to differential intrinsic sensitivity of neural progenitor cells (NPCs) from the dHi, iHi, or vHi to the stress hormone, corticosterone, or the glucocorticoid receptor (GR) agonist, dexamethasone. Long-term exposure of rat NPCs to corticosterone or dexamethasone decreased neuronal differentiation in the vHi but not the dHi, while iHi cultures showed an intermediate response. A similar gradient-like response on neuronal differentiation and maturation was observed with dexamethasone treatment. This gradient-like effect was also observed on GR nuclear translocation in response to corticosterone or dexamethasone. Long-term exposure to corticosterone or dexamethasone treatment also tended to induce a greater downregulation of GR-associated genes in vHi-derived neurons compared to those from the dHi and iHi. These data suggest that increased intrinsic sensitivity of vHi NPC-derived neurons to chronic glucocorticoid exposure may underlie the increased vulnerability of the vHi to chronic stress-induced reductions in neurogenesis.
(© 2020. The Author(s), under exclusive licence to Springer Nature Limited.)
Databáze: MEDLINE
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