Anesthesia Protocols used to Create Ischemia Reperfusion Myocardial Infarcts in Swine.

Autor: Cobo AA; Jesús Usón Minimally Invasive Surgery Centre, Cáceres, Spain;, Email: aabad@ccmijesususon.com., Margallo FMS; Jesús Usón Minimally Invasive Surgery Centre, Cáceres, Spain; CIBERCV, Madrid, Spain., Díaz CB; Jesús Usón Minimally Invasive Surgery Centre, Cáceres, Spain; CIBERCV, Madrid, Spain., Blázquez VB; Jesús Usón Minimally Invasive Surgery Centre, Cáceres, Spain; CIBERCV, Madrid, Spain., Bueno IG; Jesús Usón Minimally Invasive Surgery Centre, Cáceres, Spain., Crisóstomo V; Jesús Usón Minimally Invasive Surgery Centre, Cáceres, Spain; CIBERCV, Madrid, Spain.
Jazyk: angličtina
Zdroj: Journal of the American Association for Laboratory Animal Science : JAALAS [J Am Assoc Lab Anim Sci] 2020 Sep 01; Vol. 59 (5), pp. 478-487. Date of Electronic Publication: 2020 Jul 24.
DOI: 10.30802/AALAS-JAALAS-19-000137
Abstrakt: The porcine ischemia-reperfusion model is one of the most commonly used for cardiology research and for testing interventions for myocardial regeneration. In creating ischemic reperfusion injury, the anesthetic protocol is important for assuring hemodynamic stability of the animal during the induction of the experimental lesion and may affect its postoperative survival. This paper reviews the many drugs and anesthetic protocols used in recent studies involving porcine models of ischemiareperfusion injury. The paper also summarizes the most important characteristics of some commonly used anesthetic drugs. Literature was selected for inclusion in this review if the authors described the anesthetic protocol used and also reported the mortality rate attributed to the creation of the model. This information is an important consideration because the anesthetic protocol can influence hemodynamic stability during the experimental induction of an acute myocardial infarction, thereby impacting the survival rate and affecting the number of animals needed for each study.
Databáze: MEDLINE
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