Acrylic Bone Cement Incorporated with Low Chitosan Loadings.

Autor: Valencia Zapata ME; Grupo de Materiales Compuestos, Escuela de Ingeniería de Materiales, Universidad del Valle, Calle 13 #, Cali 100-00, Colombia., Mina Hernandez JH; Grupo de Materiales Compuestos, Escuela de Ingeniería de Materiales, Universidad del Valle, Calle 13 #, Cali 100-00, Colombia., Grande Tovar CD; Grupo de Investigación de Fotoquímica y Fotobiología, Universidad del Atlántico, Carrera 30 Número 8-49 Puerto Colombia 081008, Colombia.
Jazyk: angličtina
Zdroj: Polymers [Polymers (Basel)] 2020 Jul 21; Vol. 12 (7). Date of Electronic Publication: 2020 Jul 21.
DOI: 10.3390/polym12071617
Abstrakt: Despite the potential of acrylic bone cement (ABC) loaded with chitosan (CS) for orthopedic applications, there are only a few in vitro studies of this composite with CS loading ≤ 15 wt.% evaluated in bioactivity tests in simulated body fluid (SBF) for duration > 30 days. The purpose of the present work was to address this shortcoming of the literature. In addition to bioactivity, a wide range of cement properties were determined for composites with CS loading ranging from 0 to 20 wt.%. These properties included maximum exotherm temperature ( T max ), setting time ( t set ), water contact angle, residual monomer content, flexural strength, bending modulus, glass transition temperature, and water uptake. For cement with CS loading ≥ 15 wt.%, there was an increase in bioactivity, increase in biocompatibility, decrease in T max , increase in t set , all of which are desirable trends, but increase in residual monomer content and decrease in each of the mechanical properties, with each of these trends, were undesirable. Thus, a composite with CS loading of 15 wt.% should be further characterized to explore its suitability for use in low-weight-bearing applications, such as bone void filler and balloon kyphoplasty.
Databáze: MEDLINE
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