| Autor: |
Palanca M; Department of Oncology and Metabolism and INSIGNEO Institute for in Silico Medicine, The University of Sheffield, Pam Liversidge Building, Sheffield S1 3JD, UK.; Department of Industrial Engineering, School of Engineering and Architecture, Alma Mater Studiorum-Università di Bologna, Via Terracini 24-28, 40131 Bologna, Italy., Cristofolini L; Department of Industrial Engineering, School of Engineering and Architecture, Alma Mater Studiorum-Università di Bologna, Via Terracini 24-28, 40131 Bologna, Italy., Gasbarrini A; Department of Oncological and Degenerative Spine Surgery, IRCCS Istituto Ortopedico Rizzoli, Via G.C. Pupilli, 1-40136 Bologna, Italy., Tedesco G; Department of Oncological and Degenerative Spine Surgery, IRCCS Istituto Ortopedico Rizzoli, Via G.C. Pupilli, 1-40136 Bologna, Italy., Barbanti-Bròdano G; Department of Oncological and Degenerative Spine Surgery, IRCCS Istituto Ortopedico Rizzoli, Via G.C. Pupilli, 1-40136 Bologna, Italy. |
| Abstrakt: |
Patients spend months between the primary spinal tumor diagnosis and the surgical treatment, due to the need for performing chemotherapy and/or radiotherapy. During this period, they are exposed to an unknown risk of fracture. The aim of this study was to assess if it is possible to measure the mechanical strain in vertebrae affected by primary tumors, so as to open the way to an evidence-based scoring or prediction tool. We performed biomechanical tests on three vertebrae with bone tumor removed from patients. The tests were designed so as not to compromise the standard surgical and diagnostic procedures. Non-destructive mechanical tests in combination with state-of-the-art digital image correlation allowed to measure the distribution of strain on the surface of the vertebra. Our study has shown that the strains in the tumor region is circa 3 times higher than in the healthy bones, with principal strain peaks of 40,000/-20,000 microstrain, indicating a stress concentration potentially triggering vertebral fracture. This study has proven it is possible to analyze the mechanical behavior of primary tumor vertebrae as part of the clinical treatment protocol. This will allow building a tool for quantifying the risk of fracture and improving decision making in spine tumors. |
