Anti-LRP2 nephropathy with concurrent kidney infiltration by lymphoma.

Autor: Gamayo A; Department of Pathology, Oregon Health & Science University, Portland, OR, USA., Hecox D; Renal Care Consultants, Medford, OR, USA., Dicker L; Kidney Care Physicians, Salem, OR, USA., Vecchiarelli L; Department of Pathology, Oregon Health & Science University, Portland, OR, USA., Raess PW; Department of Pathology, Oregon Health & Science University, Portland, OR, USA., Khalighi M; Department of Pathology, Oregon Health & Science University, Portland, OR, USA., Andeen NK; Department of Pathology, Oregon Health & Science University, Portland, OR, USA.
Jazyk: angličtina
Zdroj: Clinical kidney journal [Clin Kidney J] 2019 Dec 22; Vol. 13 (3), pp. 468-472. Date of Electronic Publication: 2019 Dec 22 (Print Publication: 2020).
DOI: 10.1093/ckj/sfz166
Abstrakt: Anti-low-density lipoprotein receptor-related lipoprotein 2 (LRP2) nephropathy/anti-brush border antibody disease is rare and characterized by tubular basement membrane, Bowman's capsule and glomerular subepithelial immune deposits on kidney biopsy. No reported cases have occurred in patients with lymphoproliferative disorders or monoclonal gammopathies. We present two cases of anti-LRP2 nephropathy that occurred in patients with progressive low-grade B-cell lymphoma and had concurrent kidney infiltration by lymphoma on biopsy. We speculate that underlying immune dysregulation related to lymphoma may contribute to the development of this rare autoimmune kidney disease in some patients.
(© The Author(s) 2019. Published by Oxford University Press on behalf of ERA-EDTA.)
Databáze: MEDLINE
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