A synchronous papillary and follicular thyroid carcinoma presenting as a large toxic nodule in a female adolescent.

Autor: Van Vlaenderen J; Department of Pediatric Endocrinology, University Hospital Ghent, Corneel Heymanslaan 10, 9000 Ghent, Belgium., Logghe K; Department of Pediatrics, AZ Delta, Roeselare, Brugsesteenweg 90, 8800 Roeselare, Belgium., Schiettecatte E; Department of Radiology, University Hospital Ghent, Corneel Heymanslaan 10, 9000 Ghent, Belgium., Vermeersch H; Department of Head and Neck Surgery, University Hospital Ghent, Corneel Heymanslaan 10, 9000 Ghent, Belgium., Huvenne W; Department of Head and Neck Surgery, University Hospital Ghent, Corneel Heymanslaan 10, 9000 Ghent, Belgium., De Waele K; Department of Pediatric Endocrinology, University Hospital Ghent, Corneel Heymanslaan 10, 9000 Ghent, Belgium., Van Beveren H; Department of Pathology, University Hospital Ghent, Corneel Heymanslaan 10, 9000 Ghent, Belgium., Van Dorpe J; Department of Pathology, University Hospital Ghent, Corneel Heymanslaan 10, 9000 Ghent, Belgium., Creytens D; Department of Pathology, University Hospital Ghent, Corneel Heymanslaan 10, 9000 Ghent, Belgium., De Schepper J; Department of Pediatric Endocrinology, University Hospital Ghent, Corneel Heymanslaan 10, 9000 Ghent, Belgium.; Department of Pediatric Endocrinology, University Hospital Brussels, Laarbeeklaan 101, 1090 Brussels, Belgium.
Jazyk: angličtina
Zdroj: International journal of pediatric endocrinology [Int J Pediatr Endocrinol] 2020; Vol. 2020, pp. 14. Date of Electronic Publication: 2020 Jul 21.
DOI: 10.1186/s13633-020-00084-4
Abstrakt: Case Presentation: We report for the first time a synchronous papillary and follicular thyroid carcinoma in a 12-year-old girl presenting with a large (5 cm diameter) left thyroid nodule, an increased left and right upper pole technetium tracer uptake at scintigraphy and hyperthyroidism. The uptake at the right lobe was explained by the crossing of the left nodule to the right site of the neck at Computed Tomography (CT) scanning.
Background: Although thyroid nodules are less common in children than in adults, there is more vigilance required in children because of the higher risk of malignancy. According to literature, about 5% of the thyroid nodules in adults are malignant versus 20-26% in children. The characteristics of 9 other pediatric cases with a differentiated thyroid carcinoma presenting with a toxic nodule, which have been reported during the last 20 years, are summarized. A nodular size of more than 3.5 cm and female predominance was a common finding.
Conclusions: The presence of hyperthyroidism in association with a hyperfunctioning thyroid nodule does not rule out thyroid cancer and warrants careful evaluation, even in the absence of cervical lymph node invasion.
Competing Interests: Competing interestsThe authors declare that they have no competing interests.
(© The Author(s) 2020.)
Databáze: MEDLINE
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