Ex vivo cultivated oral mucosal epithelial cell transplantation for limbal stem cell deficiency: a review.

Autor: Cabral JV; Laboratory of the Biology and Pathology of the Eye, Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic., Jackson CJ; Department of Medical Biochemistry, Oslo University Hospital, Oslo, Norway.; Department of Oral Biology, Faculty of Dentistry, University of Oslo, Oslo, Norway.; Department of Plastic and Reconstructive Surgery, Oslo University Hospital, Oslo, Norway., Utheim TP; Department of Medical Biochemistry, Oslo University Hospital, Oslo, Norway.; Department of Plastic and Reconstructive Surgery, Oslo University Hospital, Oslo, Norway.; Department of Ophthalmology, Sørlandet Hospital Trust Arendal, Arendal, Norway., Jirsova K; Laboratory of the Biology and Pathology of the Eye, Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic. katerina.jirsova@lf1.cuni.cz.
Jazyk: angličtina
Zdroj: Stem cell research & therapy [Stem Cell Res Ther] 2020 Jul 21; Vol. 11 (1), pp. 301. Date of Electronic Publication: 2020 Jul 21.
DOI: 10.1186/s13287-020-01783-8
Abstrakt: Destruction or dysfunction of limbal epithelial stem cells (LESCs) leads to unilateral or bilateral limbal stem cell deficiency (LSCD). Fifteen years have passed since the first transplantation of ex vivo cultivated oral mucosal epithelial cells (COMET) in humans in 2004, which represents the first use of a cultured non-limbal autologous cell type to treat bilateral LSCD. This review summarizes clinical outcomes from COMET studies published from 2004 to 2019 and reviews results with emphasis on the culture methods by which grafted cell sheets were prepared.
Databáze: MEDLINE
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