Is placental KISS-1 expression associated with first trimester abortion spontaneous?

Autor:	Colak E; Department of Gynecology and Obstetrics, Konya Medical and Research Center, Baskent University School of Medicine, Konya, Turkey., Ozcimen EE; Department of Gynecology and Obstetrics, Konya Medical and Research Center, Baskent University School of Medicine, Konya, Turkey., Erinanç OH; Department of Pathology, Konya Medical and Research Center, Baskent University School of Medicine, Konya, Turkey., Tohma YA; Department of Gynecology and Obstetrics, Baskent University School of Medicine, Ankara, Turkey., Ceran MU; Department of Gynecology and Obstetrics, Konya Medical and Research Center, Baskent University School of Medicine, Konya, Turkey.
Jazyk:	angličtina
Zdroj:	Obstetrics & gynecology science [Obstet Gynecol Sci] 2020 Jul; Vol. 63 (4), pp. 490-496. Date of Electronic Publication: 2020 Jul 01.
DOI:	10.5468/ogs.19242
Abstrakt:	Objective: Several studies have examined biological markers during the first trimester to predict the maintenance of a healthy pregnancy. One such marker is kisspeptin, which is encoded by the KISS-1 gene. We aimed to determine whether firsttrimester pregnancy losses were associated with levels of placental KISS-1 expression. Methods: This prospective case control study was conducted at a tertiary center. The study group included 27 and 24 patients who underwent dilation and curettage at <10 weeks of gestation, due to first trimester spontaneous pregnancy loss and for elective termination (control), respectively. Placental and decidual tissues from all patients were sectioned and immunohistochemically analyzed for kisspeptin. Results: Age, gravida status, parity number, gestational week, and number of previous abortions did not significantly differ between the groups. KISS-1 expression levels were significantly lower in the group with spontaneous abortion compared with the group with elective termination. The median staining intensity of KISS-1 expression in the elective and spontaneous termination groups were 3 (strong) and 2 (moderate), respectively (P=0.004). KISS-1 expression levels were significantly lower among patients with previous abortions in the elective termination group (P=0.002). Conclusion: KISS-1 expression levels were found to be significantly reduced in patients with spontaneous pregnancy loss; KISS-1 plays an important role in the implantation and continuation of pregnancy.
Databáze:	MEDLINE
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