The effect of antenatal magnesium sulfate on intraventricular hemorrhage in premature infants: a systematic review and meta-analysis.

Autor:	Moradi Y; Student Research Committee, Iran University of Medical Sciences, Tehran, Iran., Khateri R; Student Research Committee, Kurdistan University of Medical Sciences, Sanandaj, Iran., Haghighi L; Department of Obstetrics and Gynecology, Iran University of Medical Sciences, Tehran, Iran., Dehghani S; Student Research Committee, Kurdistan University of Medical Sciences, Sanandaj, Iran., Hanis SM; School of Public Health, Dezful University of Medical Sciences, Dezful, Iran., Valipour M; Department of Epidemiology, School of Public Health, Iran University of Medical Sciences, Tehran, Iran., Najmi Z; Department of Obstetrics and Gynecology, Fellowship of Minimally Invasive Surgery, Zanjan University of Medical Sciences, Zanjan, Iran., Fathollahy Z; Sama Technical and Vocational Training College Tehran Branch (Tehransar), Islamic Azad University, Tehran, Iran., Allahmoradi M; Department of Physical Education and Sport Sciences, Baneh Branch, Islamic Azad University, Baneh, Iran., Mansori K; Department of Biostatistics and Epidemiology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran.
Jazyk:	angličtina
Zdroj:	Obstetrics & gynecology science [Obstet Gynecol Sci] 2020 Jul; Vol. 63 (4), pp. 395-406. Date of Electronic Publication: 2020 Jun 24.
DOI:	10.5468/ogs.19210
Abstrakt:	Objective: The aim of this systematic review and meta-analysis study was to determine the pooled estimate of the effect of antenatal magnesium sulfate (MgSO4) on intraventricular hemorrhage (IVH) in premature infants. Methods: Two review authors independently searched all randomized clinical trials from international databases, including Medline (PubMed), Web of Sciences, Scopus, Cochrane Central Register of Controlled Trials (CENTRAL), and Research Registers of ongoing trials (ClinicalTrials.gov), from January 1989 to August 2017. Two independent review authors were responsible for data collection. After extracting the necessary information from the evaluated articles, metaanalysis of the data was performed using Stata version 14. Also, sources of heterogeneity among studies were determined by Meta regression. Results: In this study, among 126 articles that were extracted from primary studies, 7 papers that evaluated the effect of MgSO4 on IVH were eligible for inclusion in the meta-analysis. The results of the meta-analysis showed that pooled relative risk (95% confidence interval [CI]) was 0.80 (95% CI, 0.63 to 1.03) for the effect of MgSO4 on IVH. Results: of this study showed that although MgSO4 had a protective effect on IVH in premature infants, this effect was not statistically significant. Further studies are needed to determine the best dosage, timing, and gestational age to achieve the optimum effect of MgSO4 on IVH. Systematic Review Registration: International Prospective Register of Systematic Reviews (PROSPERO) Identifier: CRD42019119610.
Databáze:	MEDLINE
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