Mechanobiology of neural development.

Autor: Abuwarda H; Department of Physiology & Biophysics, UC Irvine, Irvine, CA, USA; Sue and Bill Gross Stem Cell Research Center, UC Irvine, Irvine, CA, USA., Pathak MM; Department of Physiology & Biophysics, UC Irvine, Irvine, CA, USA; Sue and Bill Gross Stem Cell Research Center, UC Irvine, Irvine, CA, USA; Center for Complex Biological Systems, UC Irvine, Irvine, CA, USA; Department of Biomedical Engineering, UC Irvine, Irvine, CA, USA. Electronic address: medhap@uci.edu.
Jazyk: angličtina
Zdroj: Current opinion in cell biology [Curr Opin Cell Biol] 2020 Oct; Vol. 66, pp. 104-111. Date of Electronic Publication: 2020 Jul 17.
DOI: 10.1016/j.ceb.2020.05.012
Abstrakt: As the brain develops, proliferating cells organize into structures, differentiate, migrate, extrude long processes, and connect with other cells. These biological processes produce mechanical forces that further shape cellular dynamics and organ patterning. A major unanswered question in developmental biology is how the mechanical forces produced during development are detected and transduced by cells to impact biochemical and genetic programs of development. This gap in knowledge stems from a lack of understanding of the molecular players of cellular mechanics and an absence of techniques for measuring and manipulating mechanical forces in tissue. In this review article, we examine recent advances that are beginning to clear these bottlenecks and highlight results from new approaches that reveal the role of mechanical forces in neurodevelopmental processes.
Competing Interests: Conflict of interest statement Nothing declared.
(Copyright © 2020 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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