Pediatric low grade focal brainstem glioma: outcomes of different treatment strategies and prognostic factors.

Autor: Elmaraghi C; Department of Clinical Oncology, Ain Shams University, Cairo, Egypt.; Department of Radiotherapy, Children's Cancer Hospital, CCHE 57357, Egypt., Bishr MK; Department of Clinical Oncology, University College London Hospitals NHS Foundation Trust, London, UK., Mousa AG; National Cancer Institute, Cairo University, Cairo, Egypt.; Oncology Center, King Faisal Specialized Hospital & Research Center, Riyadh, Saudi Arabia., Ahmed S; Department of Radiotherapy, Children's Cancer Hospital, CCHE 57357, Egypt.; Department of Clinical Oncology and Nuclear Medicine. Aswan University., Refaat A; National Cancer Institute, Cairo University, Cairo, Egypt.; Department of Radiodiagnosis, Children's Cancer Hospital, CCHE 57357, Egypt., Elhemaly A; National Cancer Institute, Cairo University, Cairo, Egypt.; Department of Pediatric Oncology, Children's Cancer Hospital, CCHE 57357, Egypt., Ayadi ME; National Cancer Institute, Cairo University, Cairo, Egypt.; Department of Pediatric Oncology, Children's Cancer Hospital, CCHE 57357, Egypt., Taha H; National Cancer Institute, Cairo University, Cairo, Egypt.; Department of Pathology, Children's Cancer Hospital, CCHE 57357, Egypt., Maher E; Department of Research, Children's Cancer Hospital, CCHE 57357, Egypt., Elbeltagy M; Department of Neurosurgery, Children's Cancer Hospital, CCHE 57357, Egypt.; Faculty of Medicine, Cairo University, Cairo, Egypt., Zaghloul MS; Department of Radiotherapy, Children's Cancer Hospital, CCHE 57357, Egypt.; National Cancer Institute, Cairo University, Cairo, Egypt.
Jazyk: angličtina
Zdroj: Future oncology (London, England) [Future Oncol] 2020 Oct; Vol. 16 (30), pp. 2401-2410. Date of Electronic Publication: 2020 Jul 20.
DOI: 10.2217/fon-2020-0448
Abstrakt: Background: This study explores the prognostic factors and outcomes of different treatment modalities in focal brain stem glioma (FBSG). Materials & methods: Pediatric FBSG patients diagnosed during 2010-2017 were retrospectively reviewed for clinical and therapeutic data. Results: A total of 71 cases were identified and the median age was 6.4 years. The 5-year overall- and progression-free survival were 74.5 and 70.6%, respectively. Radiotherapy was the main line of treatment (66.2%) and there were no survival differences between radiotherapy, chemotherapy and surveillance groups. Two independent poor prognostic factors were identified on multivariate analysis: age <8 years and cervicomedullary tumor site (p = 0.02 for both). Conclusion: Surveillance, radiotherapy and chemotherapy have comparable clinical outcomes in pediatric FBSG.
Databáze: MEDLINE