Spirometric abnormalities following treatment for pulmonary tuberculosis in Ilorin, Nigeria.

Autor:	Ojuawo OB; Department of Medicine, University of Ilorin Teaching Hospital, Ilorin, Kwara State, Nigeria., Fawibe AE; Department of Medicine, University of Ilorin Teaching Hospital, Ilorin, Kwara State, Nigeria., Desalu OO; Department of Medicine, University of Ilorin Teaching Hospital, Ilorin, Kwara State, Nigeria., Ojuawo AB; Department of Paediatrics, University of Ilorin Teaching Hospital, Ilorin, Kwara State, Nigeria., Aladesanmi AO; Department of Medicine, University of Ilorin Teaching Hospital, Ilorin, Kwara State, Nigeria., Opeyemi CM; Department of Medicine, University of Ilorin Teaching Hospital, Ilorin, Kwara State, Nigeria., Adio MO; Department of Medicine, University of Ilorin Teaching Hospital, Ilorin, Kwara State, Nigeria., Salami AK; Department of Medicine, University of Ilorin Teaching Hospital, Ilorin, Kwara State, Nigeria.
Jazyk:	angličtina
Zdroj:	The Nigerian postgraduate medical journal [Niger Postgrad Med J] 2020 Jul-Sep; Vol. 27 (3), pp. 163-170.
DOI:	10.4103/npmj.npmj_18_20
Abstrakt:	Background: Pulmonary tuberculosis (PTB) contributes significantly to morbidity and mortality worldwide, and despite microbiological cure for the disease, many patients still demonstrate residual respiratory symptoms and spirometric abnormalities. Aim and Objectives: The study aimed at identifying the prevalence, pattern and factors associated with spirometric abnormalities in patients successfully treated for PTB in Ilorin, Nigeria. Materials and Methods: This was a hospital-based cross-sectional study at the pulmonary outpatient clinics of the University of Ilorin Teaching Hospital and Kwara State Specialist Hospital, Sobi, Ilorin. A total of 308 consenting patients who had been certified microbiologically cured for bacteriologically confirmed PTB in the preceding 3 years had assessment of residual pulmonary symptoms, spirometry and plain chest radiograph. Results: The prevalence of abnormal spirometry following treatment for PTB was 72.1% (confidence interval: 0.6682-0.7695), with restrictive pattern being the predominant abnormality (42.2%). Over half of the patients (56.5%) had at least one residual respiratory symptom. The significant predictors of abnormal spirometry were PTB retreatment (adjusted odds ratio [aOR] = 6.918; P = 0.012), increasing modified Medical Research Council dyspnoea scores (aOR = 7.935; P = 0.008) and increasing radiologic scores (aOR = 4.679; P ≤ 0.001) after treatment. Conclusion: There is significant residual lung function impairment in majority of the individuals successfully treated for PTB in Ilorin. This highlights the need for spirometric assessment and follow-up after treatment. Competing Interests: None
Databáze:	MEDLINE
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