The impact of vitamin D supplementation on VDR gene expression and body composition in monozygotic twins: randomized controlled trial.

Autor: Medeiros JFP; Department of Health Sciences, Federal University of Rio Grande Do Norte, Av. General Cordeiro de Farias, S/N - Petrópolis, Natal, RN, 59012-570, Brazil. jeanefpires@hotmail.com., de Oliveira Borges MV; Department of Health Sciences, Federal University of Rio Grande Do Norte, Av. General Cordeiro de Farias, S/N - Petrópolis, Natal, RN, 59012-570, Brazil., Soares AA; Department of Health Sciences, Federal University of Rio Grande Do Norte, Av. General Cordeiro de Farias, S/N - Petrópolis, Natal, RN, 59012-570, Brazil., Dos Santos JC; Department of Pharmaceutical Sciences, Faculty of Pharmacy, Federal University of Rio Grande Do Norte, Natal, RN, Brazil., de Oliveira ABB; Department of Pharmaceutical Sciences, Faculty of Pharmacy, Federal University of Rio Grande Do Norte, Natal, RN, Brazil., da Costa CHB; Department of Pharmaceutical Sciences, Faculty of Pharmacy, Federal University of Rio Grande Do Norte, Natal, RN, Brazil., Cruz MS; Department of Health Sciences, Federal University of Rio Grande Do Norte, Av. General Cordeiro de Farias, S/N - Petrópolis, Natal, RN, 59012-570, Brazil., Bortolin RH; Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of Sao Paulo, Sao Paulo, SP, Brazil., de Freitas RCC; Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of Sao Paulo, Sao Paulo, SP, Brazil., Dantas PMS; Department of Health Sciences, Federal University of Rio Grande Do Norte, Av. General Cordeiro de Farias, S/N - Petrópolis, Natal, RN, 59012-570, Brazil., Hirata MH; Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of Sao Paulo, Sao Paulo, SP, Brazil., Silbiger VN; Graduate Program in Pharmaceutical Sciences, Faculty of Pharmacy, Federal University of Rio Grande Do Norte, Natal, RN, Brazil.; Department of Clinical and Toxicological Analyses, Federal University of Rio Grande Do Norte, Natal, RN, Brazil., Luchessi AD; Department of Health Sciences, Federal University of Rio Grande Do Norte, Av. General Cordeiro de Farias, S/N - Petrópolis, Natal, RN, 59012-570, Brazil.; Graduate Program in Pharmaceutical Sciences, Faculty of Pharmacy, Federal University of Rio Grande Do Norte, Natal, RN, Brazil.; Department of Clinical and Toxicological Analyses, Federal University of Rio Grande Do Norte, Natal, RN, Brazil.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2020 Jul 20; Vol. 10 (1), pp. 11943. Date of Electronic Publication: 2020 Jul 20.
DOI: 10.1038/s41598-020-69128-2
Abstrakt: Vitamin D supplementation is widely used. However, there is no consensus on the use and dosage of this supplement and the existing recommendations arise from studies based on the benefits that this nutrient can facilitate in bones. In addition, individual genetics can influence the response to supplementation, therefore, research involving monozygotic twins aims to reduce these differences in phenotypic responses. The objective of this randomised controlled study is to examine the effect of vitamin D supplementation on body composition and the expression of the vitamin D receptor (VDR) mRNA. An intervention was performed through supplementation with cholecalciferol at the concentration of 2000 IU in 90 healthy adult monozygotic twins (male or female pairs) for 2 months. The findings showed that serum vitamin D concentration increased by 65% and VDR gene expression sixty times (p = 0.001). Changes in body composition parameters were observed regarding body fat and lean mass. Our results indicate that an increase in serum vitamin D concentration may have potential therapeutic implications.
Databáze: MEDLINE
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