| Autor: |
Portela-de-Sá HHP; Graduate Program in Health and Nutrition. Universidade Estadual do Ceará., Freitas PA; Graduate Program in Health and Nutrition. Universidade Estadual do Ceará., Alves K; Graduate Program in Physiological Sciences. Universidade Estadual do Ceará., Gomes-Vasconcelos YA; Graduate Program in Physiological Sciences. Universidade Estadual do Ceará., Vasconcelos RP; Graduate Program in Physiological Sciences. Universidade Estadual do Ceará., Fonseca SGDC; Institute of Physical Education and Sports. Universidade Federal do Ceará., Santos ECD; Graduate Program in Physiological Sciences. Universidade Estadual do Ceará., Pontes EOB; Graduate Program in Physiological Sciences. Universidade Estadual do Ceará., Costa Maia CS; Graduate Program in Health and Nutrition. Universidade Estadual do Ceará., Coelho-de-Souza AN; Graduate Program in Physiological Sciences. Universidade Estadual do Ceará., Leal-Cardoso JH; Graduate Program in Physiological Sciences. Universidade Estadual do Ceará., Brito LC; Institute of Physical Education and Sports. Universidade Federal do Ceará., Oliveira AC; Graduate Program in Health and Nutrition. Universidade Estadual do Ceará. |
| Jazyk: |
angličtina |
| Zdroj: |
Nutricion hospitalaria [Nutr Hosp] 2020 Aug 27; Vol. 37 (4), pp. 763-769. |
| DOI: |
10.20960/nh.03030 |
| Abstrakt: |
Introduction: Objective: the purpose of this study was to investigate the effects of Chrysobalanus icaco on adiposity and its mechanism of action in the gene and protein expression of acetyl-CoA carboxylase (ACC), a key enzyme in lipogenesis. Method: Wistar rats were divided into a regular or control group (CG) and a high-fat diet (HFD) group. HFD was treated with saline or aqueous extract of Chrysobalanus icaco (AECI) for four weeks. Body weight and food intake were assessed. Subcutaneous, retroperitoneal and periepididymal adipose tissue samples were collected and weighed. Adipocytes from periepididymal tissue were isolated and analyzed. The gene and protein expression of ACC in subcutaneous tissue was determined. Results: AECI showed no effect on intake or body weight. However, the weight of the fat pads and the gene and protein expression of ACC were lower, and glucose tolerance was improved. Conclusion: the aqueous extract of Chrysobalanus icaco proved beneficial for the treatment of obesity, preventing fat storage and improving glycemic homeostasis. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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