Molecular Mechanisms of Ferroptosis and Its Role in Pulmonary Disease.

Autor: Tao N; Department of Respiratory Medicine and Critical Care, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, China.; Graduate School of Peking Union Medical College, Beijing 100730, China.; The MOH Key Laboratory of Geriatrics, Beijing Hospital, National Center of Gerontology, Beijing, China., Li K; Department of Respiratory Medicine and Critical Care, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, China.; Graduate School of Peking Union Medical College, Beijing 100730, China.; The MOH Key Laboratory of Geriatrics, Beijing Hospital, National Center of Gerontology, Beijing, China., Liu J; Department of Respiratory Medicine and Critical Care, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, China.; Graduate School of Peking Union Medical College, Beijing 100730, China.; The MOH Key Laboratory of Geriatrics, Beijing Hospital, National Center of Gerontology, Beijing, China.
Jazyk: angličtina
Zdroj: Oxidative medicine and cellular longevity [Oxid Med Cell Longev] 2020 Jun 26; Vol. 2020, pp. 9547127. Date of Electronic Publication: 2020 Jun 26 (Print Publication: 2020).
DOI: 10.1155/2020/9547127
Abstrakt: Ferroptosis is a new mode of cell death that is characterized by the excessive accumulation of iron and lipid peroxides. It has unique morphological changes and disparate biochemical features and plays an intricate role in many pathophysiological processes. A great deal of researches confirms that ferroptosis can be regulated by numerous molecules through different mechanisms, supporting great potentials for novel pharmacological therapeutics. Recently, several studies reveal that ferroptosis is also closely associated with the initiation and development of respiratory disease. Understanding the specific mechanism, the molecular trait of ferroptosis and their relationship with pulmonary disease could provide significant references regarding effective treatment of these obstinate disease.
Competing Interests: The authors declare that they have no conflicts of interest.
(Copyright © 2020 Ningning Tao et al.)
Databáze: MEDLINE
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