Ageing, Drosophila melanogaster and Epigenetics.

Autor: Halim MA; USM-RIKEN International Centre for Ageing Science (URICAS), Universiti Sains Malaysia, Pulau Pinang, Malaysia.; School of Biological Sciences, Universiti Sains Malaysia, Pulau Pinang, Malaysia., Tan FHP; USM-RIKEN International Centre for Ageing Science (URICAS), Universiti Sains Malaysia, Pulau Pinang, Malaysia.; School of Biological Sciences, Universiti Sains Malaysia, Pulau Pinang, Malaysia., Azlan A; USM-RIKEN International Centre for Ageing Science (URICAS), Universiti Sains Malaysia, Pulau Pinang, Malaysia.; School of Biological Sciences, Universiti Sains Malaysia, Pulau Pinang, Malaysia., Rasyid II; School of Health Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia., Rosli N; School of Biological Sciences, Universiti Sains Malaysia, Pulau Pinang, Malaysia., Shamsuddin S; USM-RIKEN International Centre for Ageing Science (URICAS), Universiti Sains Malaysia, Pulau Pinang, Malaysia.; School of Health Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia., Azzam G; USM-RIKEN International Centre for Ageing Science (URICAS), Universiti Sains Malaysia, Pulau Pinang, Malaysia.; School of Biological Sciences, Universiti Sains Malaysia, Pulau Pinang, Malaysia.
Jazyk: angličtina
Zdroj: The Malaysian journal of medical sciences : MJMS [Malays J Med Sci] 2020 May; Vol. 27 (3), pp. 7-19. Date of Electronic Publication: 2020 Jun 30.
DOI: 10.21315/mjms2020.27.3.2
Abstrakt: Ageing is a phenomenon where the accumulation of all the stresses that alter the functions of living organisms, halter them from maintaining their physiological balance and eventually lead to death. The emergence of epigenetic tremendously contributed to the knowledge of ageing. Epigenetic changes in cells or tissues like deoxyribonucleic acid (DNA) methylation, modification of histone proteins, transcriptional modification and also the involvement of non-coding DNA has been documented to be associated with ageing. In order to study ageing, scientists have taken advantage of several potential organisms to aid them in their study. Drosophila melanogaster has been an essential model in establishing current understanding of the mechanism of ageing as they possess several advantages over other competitors like having homologues to more than 75% of human disease genes, having 50% of Drosophila genes are homologues to human genes and most importantly they are genetically amenable. Here, we would like to summarise the extant knowledge about ageing and epigenetic process and the role of Drosophila as an ideal model to study epigenetics in association with ageing process.
Competing Interests: Conflict of Interest None.
(© Penerbit Universiti Sains Malaysia, 2020.)
Databáze: MEDLINE
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