Postprandial lipaemia following consumption of a meal enriched with medium chain saturated and/or long chain omega-3 polyunsaturated fatty acids. A randomised cross-over study.

Autor: Austin G; School of Health Sciences, Faculty of Health & Medicine, University of Newcastle, Callaghan, NSW, 2308, Australia; Nutraceuticals Research Program, School of Biomedical Sciences & Pharmacy, 305C Medical Sciences Building, University of Newcastle, Callaghan, NSW, 2308, Australia. Electronic address: Grace.Austin@uon.edu.au., Ferguson JJ; Nutraceuticals Research Program, School of Biomedical Sciences & Pharmacy, 305C Medical Sciences Building, University of Newcastle, Callaghan, NSW, 2308, Australia. Electronic address: Jessica.Ferguson@newcastle.edu.au., Thota RN; Nutraceuticals Research Program, School of Biomedical Sciences & Pharmacy, 305C Medical Sciences Building, University of Newcastle, Callaghan, NSW, 2308, Australia; Riddet Institute, Massey University, Palmerston North, New Zealand. Electronic address: R.Thota@massey.ac.nz., Singh H; Riddet Institute, Massey University, Palmerston North, New Zealand. Electronic address: H.Singh@massey.ac.nz., Burrows T; School of Health Sciences, Faculty of Health & Medicine, University of Newcastle, Callaghan, NSW, 2308, Australia. Electronic address: Tracy.Burrows@newcastle.edu.au., Garg ML; Nutraceuticals Research Program, School of Biomedical Sciences & Pharmacy, 305C Medical Sciences Building, University of Newcastle, Callaghan, NSW, 2308, Australia; Riddet Institute, Massey University, Palmerston North, New Zealand. Electronic address: Manohar.Garg@newcastle.edu.au.
Jazyk: angličtina
Zdroj: Clinical nutrition (Edinburgh, Scotland) [Clin Nutr] 2021 Feb; Vol. 40 (2), pp. 420-427. Date of Electronic Publication: 2020 Jul 01.
DOI: 10.1016/j.clnu.2020.06.027
Abstrakt: Background & Aims: Postprandial lipaemic response has emerged as a risk factor for cardiovascular disease. Dietary fats such as medium-chain saturated fatty acids (MCSFA) and long-chain omega-3 polyunsaturated fatty acids (LCn-3PUFA) are known to reduce postprandial lipaemic responses. The combination of the two could potentially have complementary and/or synergistic effects for optimising cardiovascular health. This study aims to investigate the effects of MCSFA (coconut oil) with or without LCn-3PUFA (fish oil) inclusion in the test meal on postprandial blood lipids in healthy adults.
Methods: In a randomised, double-blinded, placebo-controlled, 2 × 2 factorial cross-over study, participants (n = 15) were randomised to receive four standardised isocaloric test meals. Test meals include: placebo [PL, containing no fish oil (0 g EPA & DHA) or coconut oil (0 g MCSFA)], fish oil [FO, 6 g fish oil (3.85 g EPA & DHA), containing no coconut oil (0 g MCSFA)], coconut oil [CO, 18.65 g coconut oil (15 g MCSFA), containing no fish oil (0 g EPA & DHA)] and coconut oil + fish oil [COFO, 18.65 g coconut oil (15 g MCSFA) + 6 g fish oil (3.85 g EPA & DHA)]; all providing a total fat content of 33.5 g. Participants received all four treatments on four separate test days with at least 3 days washout in between. Blood parameters were measured by finger pricks at 7 timepoints between 0 and 300min. The primary outcome of this study was the change in postprandial triglycerides (TG) concentrations with secondary outcomes as total cholesterol, high-density lipoprotein cholesterol and blood glucose concentrations.
Results: TG area under the curve (AUC) (mmol/L/min) was significantly lower for FO (383.67, p = 0.0125) and COFO (299.12, p = 0.0186) in comparison to PL (409.17) only. TG incremental area under the curve (iAUC) (mmol/L/min) was significantly lower with COFO (59.67) in comparison to CO (99.86), (p = 0.0480). Compared to PL, the change in absolute TG concentrations (mmol/L) from baseline to post TG peak time (180min) after FO were significantly less at 240min (0.39 vs 0.15), 270min (0.2 vs 0.1), and 300min (0.28 vs 0.06), and after COFO was significantly less at 300min (0.28 vs 0.16) (p < 0.05). No significant differences in postprandial AUC and iAUC for any other blood parameters were reported.
Conclusions: Our study demonstrated that LCn-3PUFA with or without MCSFA but not MCSFA alone are effective in reducing postprandial TG in healthy individuals.
Competing Interests: Conflicts of interest The authors have no conflicts of interest to declare.
(Copyright © 2020 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.)
Databáze: MEDLINE
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