Macrophage migration inhibitory factor and chemokine RANTES in young pediatric patients with congenital cardiac communications: Relation to hemodynamic parameters and the presence of Down syndrome.

Autor: Souza MFS; Heart Institute, University of São Paulo School of Medicine, São Paulo, Brazil., Carvalho ES; Heart Institute, University of São Paulo School of Medicine, São Paulo, Brazil., Maeda NY; Pró-Sangue Foundation, São Paulo, Brazil., Thomaz AM; Heart Institute, University of São Paulo School of Medicine, São Paulo, Brazil., Zorzanelli L; Heart Institute, University of São Paulo School of Medicine, São Paulo, Brazil., Castro CR; Heart Institute, University of São Paulo School of Medicine, São Paulo, Brazil., Pereira J; Laboratory of Medical Investigation on Pathogenesis and Targeted Therapy in Onco-immuno-hematology (LIM-31), University of São Paulo, São Paulo, Brazil., Lopes AA; Heart Institute, University of São Paulo School of Medicine, São Paulo, Brazil. Electronic address: aablopes@usp.br.
Jazyk: angličtina
Zdroj: Cytokine [Cytokine] 2020 Oct; Vol. 134, pp. 155192. Date of Electronic Publication: 2020 Jul 16.
DOI: 10.1016/j.cyto.2020.155192
Abstrakt: Inflammation and immunity are central in the pathobiology of pulmonary vascular disorders. Preliminary headway has been made in understanding the relationships between inflammatory proteins and clinical parameters in pediatric congenital heart disease. In this study, we analyzed serum levels of macrophage migration inhibitory factor (MIF) and regulated on activation normal T cell expressed and secreted chemokine (RANTES) in 87 patients with unrestrictive congenital cardiac communications and signs of pulmonary hypertension (age 2-36 months) and 50 pediatric controls. They were investigated in relation to clinical and hemodynamic parameters and the presence of Down syndrome. Hemodynamics was assessed by transthoracic Doppler echocardiography and cardiac catheterization. Chemokines were analyzed in serum using a chemiluminescence assay. The highest MIF levels were observed in very young subjects with heightened pulmonary vascular resistance but who presented a positive response to vasodilator challenge with inhaled nitric oxide. In contrast, RANTES levels were higher in patients with pulmonary overcirculation and congestion, correlating nonlinearly with pulmonary blood flow. Levels of both chemokines were higher in subjects with Down syndrome than in nonsyndromic individuals, but the difference was observed only in patients, not in the control group. In patients with Down syndrome, there was a direct relationship between preoperative serum MIF and the level of pulmonary artery pressure observed 6 months after surgical repair of cardiac anomalies. Thus, it was interesting to observe that MIF, which is key in the innate immune response and chemokine RANTES, which is highly expressed in respiratory viral infections were related to clinical and hemodynamic abnormalities associated with pediatric congenital heart disease.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2020 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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