Evaluation of larvicidal potential against larvae of Aedes aegypti (Linnaeus, 1762) and of the antimicrobial activity of essential oil obtained from the leaves of Origanum majorana L.

Autor: Chaves RDSB; Laboratory of Pharmacognosy and Phytochemistry, Federal University of Amapá, Macapá, Amapá, Brasil., Martins RL; Laboratory of Pharmacognosy and Phytochemistry, Federal University of Amapá, Macapá, Amapá, Brasil., Rodrigues ABL; Laboratory of Pharmacognosy and Phytochemistry, Federal University of Amapá, Macapá, Amapá, Brasil., Rabelo ÉM; Laboratory of Pharmacognosy and Phytochemistry, Federal University of Amapá, Macapá, Amapá, Brasil., Farias ALF; Laboratory of Pharmacognosy and Phytochemistry, Federal University of Amapá, Macapá, Amapá, Brasil., Brandão LB; Laboratory of Pharmacognosy and Phytochemistry, Federal University of Amapá, Macapá, Amapá, Brasil., Santos LL; Laboratory of Pharmacognosy and Phytochemistry, Federal University of Amapá, Macapá, Amapá, Brasil., Galardo AKR; Laboratory of Entomology Medical of Institute of Scientific and Technological Research of the State of Amapá (IEPA), Macapá, Amapá, Brasil., de Almeida SSMDS; Laboratory of Pharmacognosy and Phytochemistry, Federal University of Amapá, Macapá, Amapá, Brasil.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2020 Jul 17; Vol. 15 (7), pp. e0235740. Date of Electronic Publication: 2020 Jul 17 (Print Publication: 2020).
DOI: 10.1371/journal.pone.0235740
Abstrakt: This study evaluated the larvicidal activity of Origanum majorana Linnaeus essential oil, identified the chemical composition, evaluated the antimicrobial, cytotoxic and antioxidant potential. The larvicidal activity was evaluated against larvae of the third stage of Aedes aegypti Linaeus, whereas the chemical composition was identified by gas chromatography coupled to mass spectrometer, the antimicrobial activity was carried out against the bacteria Pseudomonas aeruginosa, Escherichia coli and Staphylococcus auereus, the antioxidant activity was evaluated from of 2.2-diphenyl-1-picryl-hydrazila sequestration and Artemia salina Leach cytotoxicity. Regarding to the results, the larvicidal activity showed that O. majorana L. essential oil caused high mortality in A. aegypti L. larvae. In the chromatographic analysis, the main component found in O. majorana L. essential oil was pulegone (57.05%), followed by the other components verbenone (16.92%), trans-p-menthan-2-one (8.57%), iso-menthone (5.58%), piperitone (2.83%), 3-octanol (2.35%) and isopulegol (1.47%). The antimicrobial activity showed that E. coli and P. aeruginosa bacteria were more sensitive to oil than S. aureus, which was resistant at all concentrations. Essential oil did not present antioxidant activity, but it has high cytotoxic activity against A. salina L.
Competing Interests: The authors have declared that no competing interests exist.
Databáze: MEDLINE
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