Rapid SARS-CoV-2 whole-genome sequencing and analysis for informed public health decision-making in the Netherlands.

Autor: Oude Munnink BB; ErasmusMC, Department of Viroscience, WHO Collaborating Centre for Arbovirus and Viral Hemorrhagic Fever Reference and Research, Rotterdam, the Netherlands., Nieuwenhuijse DF; ErasmusMC, Department of Viroscience, WHO Collaborating Centre for Arbovirus and Viral Hemorrhagic Fever Reference and Research, Rotterdam, the Netherlands., Stein M; Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, the Netherlands., O'Toole Á; Institute of Evolutionary Biology, University of Edinburgh, Edinburgh, UK., Haverkate M; Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, the Netherlands., Mollers M; Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, the Netherlands., Kamga SK; Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, the Netherlands., Schapendonk C; ErasmusMC, Department of Viroscience, WHO Collaborating Centre for Arbovirus and Viral Hemorrhagic Fever Reference and Research, Rotterdam, the Netherlands., Pronk M; ErasmusMC, Department of Viroscience, WHO Collaborating Centre for Arbovirus and Viral Hemorrhagic Fever Reference and Research, Rotterdam, the Netherlands., Lexmond P; ErasmusMC, Department of Viroscience, WHO Collaborating Centre for Arbovirus and Viral Hemorrhagic Fever Reference and Research, Rotterdam, the Netherlands., van der Linden A; ErasmusMC, Department of Viroscience, WHO Collaborating Centre for Arbovirus and Viral Hemorrhagic Fever Reference and Research, Rotterdam, the Netherlands., Bestebroer T; ErasmusMC, Department of Viroscience, WHO Collaborating Centre for Arbovirus and Viral Hemorrhagic Fever Reference and Research, Rotterdam, the Netherlands., Chestakova I; ErasmusMC, Department of Viroscience, WHO Collaborating Centre for Arbovirus and Viral Hemorrhagic Fever Reference and Research, Rotterdam, the Netherlands., Overmars RJ; ErasmusMC, Department of Viroscience, WHO Collaborating Centre for Arbovirus and Viral Hemorrhagic Fever Reference and Research, Rotterdam, the Netherlands., van Nieuwkoop S; ErasmusMC, Department of Viroscience, WHO Collaborating Centre for Arbovirus and Viral Hemorrhagic Fever Reference and Research, Rotterdam, the Netherlands., Molenkamp R; ErasmusMC, Department of Viroscience, WHO Collaborating Centre for Arbovirus and Viral Hemorrhagic Fever Reference and Research, Rotterdam, the Netherlands., van der Eijk AA; ErasmusMC, Department of Viroscience, WHO Collaborating Centre for Arbovirus and Viral Hemorrhagic Fever Reference and Research, Rotterdam, the Netherlands., GeurtsvanKessel C; ErasmusMC, Department of Viroscience, WHO Collaborating Centre for Arbovirus and Viral Hemorrhagic Fever Reference and Research, Rotterdam, the Netherlands., Vennema H; Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, the Netherlands., Meijer A; Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, the Netherlands., Rambaut A; Institute of Evolutionary Biology, University of Edinburgh, Edinburgh, UK., van Dissel J; Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, the Netherlands., Sikkema RS; ErasmusMC, Department of Viroscience, WHO Collaborating Centre for Arbovirus and Viral Hemorrhagic Fever Reference and Research, Rotterdam, the Netherlands., Timen A; Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, the Netherlands., Koopmans M; ErasmusMC, Department of Viroscience, WHO Collaborating Centre for Arbovirus and Viral Hemorrhagic Fever Reference and Research, Rotterdam, the Netherlands. m.koopmans@erasmusmc.nl.
Jazyk: angličtina
Zdroj: Nature medicine [Nat Med] 2020 Sep; Vol. 26 (9), pp. 1405-1410. Date of Electronic Publication: 2020 Jul 16.
DOI: 10.1038/s41591-020-0997-y
Abstrakt: In late December 2019, a cluster of cases of pneumonia of unknown etiology were reported linked to a market in Wuhan, China 1 . The causative agent was identified as the species Severe acute respiratory syndrome-related coronavirus and was named SARS-CoV-2 (ref.  2 ). By 16 April the virus had spread to 185 different countries, infected over 2,000,000 people and resulted in over 130,000 deaths 3 . In the Netherlands, the first case of SARS-CoV-2 was notified on 27 February. The outbreak started with several different introductory events from Italy, Austria, Germany and France followed by local amplification in, and later also outside, the south of the Netherlands. The combination of near to real-time whole-genome sequence analysis and epidemiology resulted in reliable assessments of the extent of SARS-CoV-2 transmission in the community, facilitating early decision-making to control local transmission of SARS-CoV-2 in the Netherlands. We demonstrate how these data were generated and analyzed, and how SARS-CoV-2 whole-genome sequencing, in combination with epidemiological data, was used to inform public health decision-making in the Netherlands.
Databáze: MEDLINE
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