Decumbic anhydride from the stem barks of Swintonia floribunda (Anacardiaceae).

Autor: Dang PH; Faculty of Chemistry, University of Science, Ho Chi Minh City, Vietnam.; Vietnam National University, Ho Chi Minh City, Vietnam., Le TH; Faculty of Chemistry, University of Science, Ho Chi Minh City, Vietnam.; Vietnam National University, Ho Chi Minh City, Vietnam., Van Do TN; Faculty of Chemistry, University of Science, Ho Chi Minh City, Vietnam.; Vietnam National University, Ho Chi Minh City, Vietnam., Nguyen HX; Faculty of Chemistry, University of Science, Ho Chi Minh City, Vietnam.; Vietnam National University, Ho Chi Minh City, Vietnam., Nguyen MTT; Faculty of Chemistry, University of Science, Ho Chi Minh City, Vietnam.; Vietnam National University, Ho Chi Minh City, Vietnam.; Cancer Research Laboratory, University of Science, Ho Chi Minh City, Vietnam., Nguyen NT; Faculty of Chemistry, University of Science, Ho Chi Minh City, Vietnam.; Vietnam National University, Ho Chi Minh City, Vietnam.; Cancer Research Laboratory, University of Science, Ho Chi Minh City, Vietnam.
Jazyk: angličtina
Zdroj: Zeitschrift fur Naturforschung. C, Journal of biosciences [Z Naturforsch C J Biosci] 2020 Jul 16; Vol. 76 (1-2), pp. 49-53. Date of Electronic Publication: 2020 Jul 16 (Print Publication: 2021).
DOI: 10.1515/znc-2020-0136
Abstrakt: From an EtOAc-soluble fraction of the stem barks of Swintonia floribunda (Anacardiaceae), decumbic anhydride ( 1 ) and four known compounds 2 - 5 were isolated. Their chemical structures were elucidated based on the spectroscopic data interpretation. The GIAO-DFT calculation of 13 C NMR chemical shifts was carried out to clarify the structure of 1 . The absolute configuration of 1 was assigned based on the Cotton effects in its ECD spectrum. Compound 1 showed potent tyrosinase inhibitory activity with an IC 50 value of 52.2 μM.
(© 2020 Walter de Gruyter GmbH, Berlin/Boston.)
Databáze: MEDLINE