Alteration of sperm parameters and reproductive hormones in Swiss mice via oxidative stress after co-exposure to titanium dioxide and zinc oxide nanoparticles.

Autor: Ogunsuyi OM; Cell Biology and Genetics Unit, Department of Zoology, University of Ibadan, Ibadan, Oyo State, Nigeria., Ogunsuyi OI; Department of Biological Sciences, Mountain Top University, Ibafo, Ogun State, Nigeria., Akanni O; Drug Metabolism and Toxicology Research Laboratory, Department of Biochemistry, University of Ibadan, Ibadan, Oyo State, Nigeria., Alabi OA; Department of Biology, Federal University of Technology, Akure, Ondo State, Nigeria., Alimba CG; Cell Biology and Genetics Unit, Department of Zoology, University of Ibadan, Ibadan, Oyo State, Nigeria., Adaramoye OA; Drug Metabolism and Toxicology Research Laboratory, Department of Biochemistry, University of Ibadan, Ibadan, Oyo State, Nigeria., Cambier S; Environmental Research and Innovation (ERIN) Department, Luxembourg Institute of Science and Technology, Belvaux, Luxembourg., Eswara S; Materials Research and Technology (MRT) Department, Luxembourg Institute of Science and Technology, Belvaux, Luxembourg., Gutleb AC; Environmental Research and Innovation (ERIN) Department, Luxembourg Institute of Science and Technology, Belvaux, Luxembourg., Bakare AA; Cell Biology and Genetics Unit, Department of Zoology, University of Ibadan, Ibadan, Oyo State, Nigeria.
Jazyk: angličtina
Zdroj: Andrologia [Andrologia] 2020 Nov; Vol. 52 (10), pp. e13758. Date of Electronic Publication: 2020 Jul 16.
DOI: 10.1111/and.13758
Abstrakt: In this study, Swiss male mice were intraperitoneally administered with titanium dioxide (TiO 2 ) and zinc oxide (ZnO) nanoparticles (NPs) and their mixture (1:1) at doses between 9.38 and 75 mg/kg for 5 weeks to evaluate reproductive toxicity. Both NPs and their mixture significantly (p < .001) altered sperm motility, reduced sperm numbers and increased abnormalities, while their mixture induced more sperm abnormalities than either TiO 2 NPs or ZnO NPs. Both NPs and their mixture significantly (p < .05) reduced the LH level, while ZnO NPs alone and their mixture (p < .001) increased the testosterone levels at tested doses. The testes of exposed mice showed pathological changes and altered histomorphometrics. TiO 2 NPs and ZnO NPs individually induced a significant (p < .01) reduction in SOD and CAT activities, while the mixture significantly (p < .001) decreased CAT activity and increased SOD activity. TiO 2 NPs alone at 9.38 mg/kg induced a significant (p < .001) reduction in the GSH level, while both NPs and their mixture increased the MDA level significantly (p < .05). The data showed that the mixture had a synergistic interaction to induce testicular damage. Overall, oxidative stress may be involved in the NP-mediated testicular damage observed.
(© 2020 Blackwell Verlag GmbH.)
Databáze: MEDLINE
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