The use of intra-operative tranexamic acid in shoulder surgery: Protocol for a systematic review and meta-analysis.
| Autor: | Hartland AW; Trauma and Orthopaedics, Princess Alexandra Hospital, Hamstel Road, Harlow, Essex CM20 1QX, UK., Teoh KH; Trauma and Orthopaedics, Princess Alexandra Hospital, Hamstel Road, Harlow, Essex CM20 1QX, UK., Rashid MS; Nuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Sciences, Windmill Road, Oxford OX3 7LD, UK. |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | International journal of surgery protocols [Int J Surg Protoc] 2020 Jun 23; Vol. 22, pp. 15-18. Date of Electronic Publication: 2020 Jun 23 (Print Publication: 2020). |
| DOI: | 10.1016/j.isjp.2020.06.003 |
| Abstrakt: | Introduction: Blood loss is an important consideration in all types of shoulder surgery. Excessive bleeding is associated with increased morbidity. Tranexamic acid (TXA) is an antifibrinolytic agent. It has been demonstrated to be effective in reducing blood loss across multiple surgical specialties. The aim of this systematic review and meta-analysis is to review the literature evaluating clinical outcomes associated with the use of TXA in shoulder surgery. Methods: The study protocol was designed and registered prospectively on PROSPERO (International prospective register for systematic reviews). Literature search will include the MEDLINE, EMBASE, PsycINFO, and Cochrane Library databases. Randomised controlled trials (RCTs) evaluating the use of TXA against placebo, in all types of shoulder surgery, will be included. Our primary outcome is total blood loss (ml). Secondary outcomes include patient-reported outcome measures (PROMs), adverse events, and number of blood transfusions required. Risk of bias will be assessed within each study using The Cochrane Risk of Bias Tool 2.0 and the Jadad score. Inconsistency and bias across included studies will be assessed statistically. Data from comparable outcomes will be pooled and analysed quantitatively or descriptively as appropriate. Ethics and Dissemination: No ethical clearances required for this study. This systematic review and meta-analysis will be published in a peer-reviewed journal. It will be presented a various national and international conferences. Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (© 2020 The Authors.) |
| Databáze: | MEDLINE |
| Externí odkaz: |
|