Preventive effects of Korean red ginseng on experimentally induced colitis and colon carcinogenesis.

Autor:	Shin HJ; Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, South Korea., Kim DH; Department of Chemistry, College of Convergence and Integrated Science, Kyonggi University, Suwon, Gyeonggi-do, South Korea., Zhong X; Tumor Microenvironment Research Center, College of Pharmacy, Seoul National University, Seoul, South Korea., Yum HW; Tumor Microenvironment Research Center, College of Pharmacy, Seoul National University, Seoul, South Korea., Kim SJ; Tumor Microenvironment Research Center, College of Pharmacy, Seoul National University, Seoul, South Korea., Chun KS; College of Pharmacy, Keimyung University, Daegu, South Korea., Na HK; Department of Food Science and Biotechnology, College of Knowledge-based Services Engineering, Sungshin Women's University, Seoul, South Korea., Surh YJ; Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, South Korea.; Tumor Microenvironment Research Center, College of Pharmacy, Seoul National University, Seoul, South Korea.; Cancer Research Institute, Seoul National University, Seoul, South Korea.
Jazyk:	angličtina
Zdroj:	Journal of traditional and complementary medicine [J Tradit Complement Med] 2020 Apr 25; Vol. 10 (3), pp. 198-206. Date of Electronic Publication: 2020 Apr 25 (Print Publication: 2020).
DOI:	10.1016/j.jtcme.2020.04.004
Abstrakt:	Korean Red Ginseng (KRG) exerts chemopreventive effects on experimentally induced carcinogenesis through multiple mechanisms. In this study, we investigated effects of KRG on dextran sulfate sodium (DSS)-induced colitis and azoxymethane (AOM) plus DSS-induced colon carcinogenesis in mice. Male C57BL/6J mice were fed diet containing 1% KRG or a standard diet throughout the experiment. The mouse colitis was induced by administration of 3% DSS in drinking water for 1 week. DSS caused body weight loss, diarrhea, rectal bleeding and colon length shortening, and all these symptoms were ameliorated by KRG treatment. KRG inhibited DSS-induced expression of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) by suppressing activation of nuclear factor-kappa B (NF-κB) and signal transducer and activation of transcription 3 (STAT3). In another experiment, colon carcinogenesis was initiated by single intraperitoneal injection of AOM (10 mg/kg) and promoted by 2% DSS in drinking water. KRG administration relieved the symptoms of colitis and reduced the incidence, the multiplicity and the size of colon tumor. The up-regulation of COX-2, iNOS, c-Myc and Cyclin D1 by AOM plus DSS was attenuated in KRG fed mice which was associated with suppression of NF-κB and STAT3 activation. These results suggest that KRG is a potential candidate for chemoprevention of inflammation-associated cancer in the colon. Competing Interests: The authors declare no conflicts of interest in this work/ (© 2020 Center for Food and Biomolecules, National Taiwan University. Production and hosting by Elsevier Taiwan LLC.)
Databáze:	MEDLINE
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