Enterovirus D-68 Molecular Virology, Epidemiology, and Treatment: an Update and Way Forward.

Autor:	Ebada MA; Faculty of Medicine, Zagazig University, Zagazig, El-Sharkia, Egypt., Fayed N; Faculty of Medicine, Zagazig University, Zagazig, El-Sharkia, Egypt., Alkanj S; Faculty of Medicine, Zagazig University, Zagazig, El-Sharkia, Egypt., Allah AW; Biochemistry Department, Faculty of Science, Ain Shams University, Cairo, Egypt.
Jazyk:	angličtina
Zdroj:	Infectious disorders drug targets [Infect Disord Drug Targets] 2021; Vol. 21 (3), pp. 320-327.
DOI:	10.2174/1871526520666200715101230
Abstrakt:	Enterovirus D68 (EV-D68) is a single-stranded positive-sense RNA virus, and it is one of the family members of Picornaviridae. Except for EV-D68, the entire family Picornaviridae has been illustrated in literature. EV-D68 was first discovered and isolated in California, USA, in 1962. EV-D68 has resulted in respiratory disorders' outbreaks among children worldwide, and it has been detected in cases of various neurological diseases such as acute flaccid myelitis (AFM). A recent study documented a higher number of EV-D68 cases associated with AFM in Europe in 2016 compared to the 2014 outbreak. EV-D68 is mainly diagnosed by quantitative PCR, and there is an affirmative strategy for EV-D68 detection by using pan-EV PCR on the untranslated region and/or the VP1 or VP2, followed by sequencing of the PCR products. Serological tests are limited due to cross-reactivity of the antigens between the different serotypes. Many antiviral drugs for EV-D68 have been evaluated and showed promising results. In our review, we discuss the current knowledge about EV-D68 and its role in the development of AFM. (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.)
Databáze:	MEDLINE
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