Theoretical and Experimental Analysis of Protoporphyrin IX Photodegradation Using Multi-Wavelength Light Sources.

Autor: Sánchez V; São Carlos Institute of Physics, University of São Paulo, São Carlos, SP, Brazil.; Gleb Wataghin Physics Institute, University of Campinas, Campinas, SP, Brazil., Garcia MR; São Carlos Institute of Physics, University of São Paulo, São Carlos, SP, Brazil., Requena MB; São Carlos Institute of Physics, University of São Paulo, São Carlos, SP, Brazil., Romano RA; São Carlos Institute of Physics, University of São Paulo, São Carlos, SP, Brazil., de Boni L; São Carlos Institute of Physics, University of São Paulo, São Carlos, SP, Brazil., Guimarães FEG; São Carlos Institute of Physics, University of São Paulo, São Carlos, SP, Brazil., Pratavieira S; São Carlos Institute of Physics, University of São Paulo, São Carlos, SP, Brazil.
Jazyk: angličtina
Zdroj: Photochemistry and photobiology [Photochem Photobiol] 2020 Nov; Vol. 96 (6), pp. 1208-1214. Date of Electronic Publication: 2020 Aug 26.
DOI: 10.1111/php.13311
Abstrakt: Photodynamic procedures have been used in many applications, ranging from cancer treatment to microorganism inactivation. Photodynamic reactions start with the activation of a photosensitizing molecule with light, leading to the production of cytotoxic molecules that promote cell death. However, establishing the correct light and photosensitizer dosimetry for a broadband light source remains challenging. In this study, we proposed a theoretical mathematical model for the photodegradation of protoporphyrin IX (PpIX), when irradiated by multi-wavelength light sources. The theoretical model predicts the experimental photobleaching (temporal change in PpIX concentration) of PpIX for different light sources. We showed that photobleaching occurs independently of the light source wavelengths but instead depends only on the number of absorbed photons. The model presented here can be used as an important mathematical approach to better understand current photodynamic therapy protocols and help achieve optimization of the doses delivered.
(© 2020 American Society for Photobiology.)
Databáze: MEDLINE
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