Depression, temporomandibular disorders, and genetic polymorphisms in IL6 impact on oral health-related quality of life in patients requiring orthognathic surgery.

Autor: Sebastiani AM; School of Health and Biological Sciences, Positivo University, Curitiba, Brazil. sebastiani.aline@gmail.com.; Department of Stomatology, Federal University of Parana, Curitiba, Brazil. sebastiani.aline@gmail.com., Dos Santos KM; School of Health and Biological Sciences, Positivo University, Curitiba, Brazil., Cavalcante RC; Department of Stomatology, Federal University of Parana, Curitiba, Brazil., Pivetta Petinati MF; School of Health and Biological Sciences, Positivo University, Curitiba, Brazil., Signorini L; School of Health and Biological Sciences, Positivo University, Curitiba, Brazil., Antunes LAA; Department of Specific Training, Dentistry, Nova Friburgo Insitute, Fluminense Federal University, Rio de Janeiro, Brazil., Rebellato NLB; Department of Stomatology, Federal University of Parana, Curitiba, Brazil., Küchler EC; School of Health and Biological Sciences, Positivo University, Curitiba, Brazil.; Department of Pediatric Dentistry, Ribeirão Preto Dental School, University of São Paulo School of dentistry of Ribeirão Preto, University of São Paulo, São Paulo, Brazil., Scariot R; School of Health and Biological Sciences, Positivo University, Curitiba, Brazil.; Department of Stomatology, Federal University of Parana, Curitiba, Brazil.
Jazyk: angličtina
Zdroj: Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation [Qual Life Res] 2020 Dec; Vol. 29 (12), pp. 3315-3323. Date of Electronic Publication: 2020 Jul 14.
DOI: 10.1007/s11136-020-02581-8
Abstrakt: Purpose: To assess oral health-related quality of life (OHRQoL) in patients requiring orthognathic surgery, and evaluate if depression, temporomandibular disorders (TMD), and genetic polymorphisms in interleukin-6 (IL6) influence their OHRQoL.
Methods: A total of 132 individuals included in three different groups. Two groups were composed by patients with dentofacial deformity (DFD) Class II (n = 44) or Class III (n = 44) malocclusions, requiring orthognathic surgery. The control group (n = 44) included individuals without DFD. Patients from all groups were evaluated in preoperative appointments to assessOHRQoL, TMD, and genetic polymorphisms in IL6. OHRQoL was assessed using the 14-item Oral Health Impact Profile (OHIP-14). TMD and depression were assessed using Research Diagnostic Criteria for Temporomandibular Disorders protocol. The genetic polymorphisms rs1800795 and rs1800796 in IL6 were assessed through genomic DNA using real-time polymerase chain reaction.
Results: OHIP-14 scores were increased in patients with depression, myofascial pain, and inflammatory temporomandibular joint alterations in the right side, regardless of sex and DFD group. Individual homozygous CC in rs1800795 had increased values in domains "social disability" and "handicap" of the OHIP-14 compared with those who were homozygous GG. Individual heterozygous CG in the rs1800796 demonstrated increased values in domain "psychological discomfort" compared with those homozygous for CC and GG.
Conclusion: In individuals requiring orthognathic surgery, depression, TMD, and genetic polymorphisms in IL6 contribute to negative impact on OHRQoL. These physical and emotional conditions, together with biological pathways, should receive more attention in treatment plans, in order to improve the patients' quality of life.
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje