Assessment of transthyretin cut-off values for a better screening of malnutrition: Retrospective determination and prospective validation.

Autor: Dellière S; Service de Biochimie, Hôpital Cochin, APHP, Paris, France., Pouga L; Service de Biochimie, Hôpital Cochin, APHP, Paris, France., Neveux N; Service de Biochimie, Hôpital Cochin, APHP, Paris, France; Laboratoire de Biologie de la Nutrition, EA4466 PRETRAM, Faculté de Pharmacie de Paris, Université de Paris, Paris, France., Hernvann A; Service de Biochimie, Hôpital Cochin, APHP, Paris, France., De Bandt JP; Service de Biochimie, Hôpital Cochin, APHP, Paris, France; Laboratoire de Biologie de la Nutrition, EA4466 PRETRAM, Faculté de Pharmacie de Paris, Université de Paris, Paris, France., Cynober L; Service de Biochimie, Hôpital Cochin, APHP, Paris, France; Laboratoire de Biologie de la Nutrition, EA4466 PRETRAM, Faculté de Pharmacie de Paris, Université de Paris, Paris, France. Electronic address: luc.cynober@aphp.fr.
Jazyk: angličtina
Zdroj: Clinical nutrition (Edinburgh, Scotland) [Clin Nutr] 2021 Mar; Vol. 40 (3), pp. 907-911. Date of Electronic Publication: 2020 Jun 25.
DOI: 10.1016/j.clnu.2020.06.017
Abstrakt: The use of transthyretin (TTR, prealbumin) as a marker of malnutrition and the definition of associated cut-offs are a matter of debate. In order to clarify this issue, we performed a retrospective study and then a prospective validation one. In the first study, data from 23,617 consecutive patients from our University hospital were analysed. Using the 0.11 and 0.05 g/L cut-off values defined by the French Health Authority, only 3.13% and 0.49% appeared malnourished or severely malnourished indicating that these cut-off values are clearly inappropriate. In the prospective study, consecutive patients were stratified for normal (≥0.2 g/L) or low (<0.2 g/L) TTR, and normal (<15 mg/L) or high (≥15 mg/L) C-reactive protein, hence defining 4 groups (n = 50 to 57/group), and data were analysed according to nutritional status estimated from patient files. Receiver operating characteristic (ROC) curve of TTR level associated with malnutrition allowed setting cut-off values at 0.17 and 0.12 g/L for malnutrition and severe malnutrition respectively.
Competing Interests: Conflict of interest None declared.
(Copyright © 2020 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.)
Databáze: MEDLINE
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