Glucocorticoids, sodium transport mediators, and respiratory distress syndrome in preterm infants.

Autor: Süvari L; Children's Hospital, Pediatric Research Center, Helsinki University and Helsinki University Hospital, Helsinki, Finland.; West Tallinn Central Hospital, Tallinn, Estonia., Helve OM; Children's Hospital, Pediatric Research Center, Helsinki University and Helsinki University Hospital, Helsinki, Finland., Kari MA; Children's Hospital, Pediatric Research Center, Helsinki University and Helsinki University Hospital, Helsinki, Finland., Turpeinen LU; HUSLAB, Helsinki University Hospital, Helsinki, Finland., Palojärvi PA; Children's Hospital, Pediatric Research Center, Helsinki University and Helsinki University Hospital, Helsinki, Finland., Leskinen MJ; Children's Hospital, Pediatric Research Center, Helsinki University and Helsinki University Hospital, Helsinki, Finland., Andersson S; Children's Hospital, Pediatric Research Center, Helsinki University and Helsinki University Hospital, Helsinki, Finland., Janér AC; Children's Hospital, Pediatric Research Center, Helsinki University and Helsinki University Hospital, Helsinki, Finland. cecilia.janer@helsinki.fi.
Jazyk: angličtina
Zdroj: Pediatric research [Pediatr Res] 2021 Apr; Vol. 89 (5), pp. 1253-1260. Date of Electronic Publication: 2020 Jul 14.
DOI: 10.1038/s41390-020-1061-9
Abstrakt: Background: Antenatal glucocorticoids (GCs) reduce respiratory distress syndrome (RDS) in preterm infants and are associated with reduced lung liquid content. Our aim was to assess whether airway gene expression of mediators of pulmonary epithelial sodium and liquid absorption, and further, respiratory morbidity, associate with cord blood GC concentrations.
Methods: The study included 64 infants delivered <32 weeks gestation. Cortisol and betamethasone in umbilical cord blood were quantified with liquid chromatography-tandem mass spectrometry. The total GC concentration was calculated. Gene expression of the epithelial sodium channel (ENaC), Na,K-ATPase, and serum- and GC-inducible kinase 1 at <2 h and at 1 day postnatally in nasal epithelial cell samples was quantified with reverse transcription-polymerase chain reaction. The mean oxygen supplementation during the first 72 h was calculated.
Results: Concentrations of cord blood betamethasone and total GC were significantly lower in infants with RDS and correlated with mean oxygen supplementation. Expression of αENaC and α1- and β1Na,K-ATPase at <2 h correlated with betamethasone and total GC concentrations. Expression of Na,K-ATPase was lower in infants with RDS.
Conclusion: Enhancement of lung liquid absorption via increased expression of sodium transporters may contribute to the beneficial pulmonary effects of antenatal GCs.
Impact: RDS is related to lower umbilical cord blood GC concentrations and lower airway expression of sodium transporters. In addition to the timing of antenatal GC treatment, resulting concentrations may be of importance in preventing RDS. Induction of sodium transport may be a factor contributing to the pulmonary response to antenatal GCs.
Databáze: MEDLINE
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