Potential clinical value of interleukin-31 and interleukin-33 with their receptors expression as diagnostic and predictive factors in endometrial cancer: a case-control study.

Autor:	Zeng X; Department of Gynecology and Obstetrics, The West China Second University Hospital, Sichuan University Chengdu 610041, China.; Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education Chengdu 610041, China., Li J; Department of Environmental and Occupational Health, West China School of Public Health, Sichuan University Chengdu, Sichuan, China., Kang LN; Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education Chengdu 610041, China.; National Office for Maternal and Child Health Surveillance of China, West China Second University Hospital, Sichuan University Chengdu, Sichuan, China., Xi MR; Department of Gynecology and Obstetrics, The West China Second University Hospital, Sichuan University Chengdu 610041, China.; Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education Chengdu 610041, China., Liao GD; Department of Gynecology and Obstetrics, The West China Second University Hospital, Sichuan University Chengdu 610041, China.; Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education Chengdu 610041, China.
Jazyk:	angličtina
Zdroj:	International journal of clinical and experimental pathology [Int J Clin Exp Pathol] 2020 Jun 01; Vol. 13 (6), pp. 1324-1332. Date of Electronic Publication: 2020 Jun 01 (Print Publication: 2020).
Abstrakt:	Aims: To evaluate the potential role of interleukin-31 and interleukin-33 in diagnosis and prognosis from endometrial cancer. Methods: Tissue samples and clinical data were collected from 260 patients with endometrial cancer and 150 control patients with benign uterine diseases. Immunohistochemistry and ELISA testing quantified the expressions of interleukin-31 and interleukin-33 and their receptors. After surgery, all patients were followed up for an average of 56.3 months. Surgical effects were evaluated based on the patients' symptoms and signs. A two-sided P value <0.05 was considered significant. Results: IL-31, IL-33 and their receptors were significantly accumulated with the progression of endometrial cancer, in comparison to the controls. Moreover, the expressions were correlated with clinical characteristics, including tumor stage, differentiation, and associated with patients' disease-free survival. Conclusions: Limited data was available between the expressions of IL-31 and IL-33 and the receptors in patients with endometrial cancer. Our study findings suggested that the expressions of IL-31 and IL-33 might become possible biomarkers for the diagnosis and prediction in endometrial cancer. Competing Interests: None. (IJCEP Copyright © 2020.)
Databáze:	MEDLINE
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