Is radial scar on core needle biopsy a risk factor for malignancy? A single-center retrospective review and implications for management.

Autor: Woodward SG; Department of Surgery, Thomas Jefferson University Hospital, Sidney Kimmel Medical College, Philadelphia University and Thomas Jefferson University, Philadelphia, PA, USA., Nimtz K; Sidney Kimmel Medical College, Philadelphia University and Thomas Jefferson University, Philadelphia, PA, USA., Hookim K; Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University Hospital, Sidney Kimmel Medical College, Philadelphia University and Thomas Jefferson University, Philadelphia, PA, USA., Sevrukov AB; Department of Radiology, Thomas Jefferson University Hospital, Sidney Kimmel Medical College, Philadelphia University and Thomas Jefferson University, Philadelphia, PA, USA., Tsangaris TN; Department of Surgery, Thomas Jefferson University Hospital, Sidney Kimmel Medical College, Philadelphia University and Thomas Jefferson University, Philadelphia, PA, USA.; Cancer Center, Calvert Health, Prince Frederick, MD, USA., Willis A; Department of Surgery, Thomas Jefferson University Hospital, Sidney Kimmel Medical College, Philadelphia University and Thomas Jefferson University, Philadelphia, PA, USA., Berger AC; Department of Surgery, Thomas Jefferson University Hospital, Sidney Kimmel Medical College, Philadelphia University and Thomas Jefferson University, Philadelphia, PA, USA.; Department of Surgery, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA., Lazar M; Department of Surgery, Thomas Jefferson University Hospital, Sidney Kimmel Medical College, Philadelphia University and Thomas Jefferson University, Philadelphia, PA, USA.
Jazyk: angličtina
Zdroj: The breast journal [Breast J] 2020 Oct; Vol. 26 (10), pp. 2011-2014. Date of Electronic Publication: 2020 Jul 13.
DOI: 10.1111/tbj.13975
Abstrakt: Introduction: Reported upgrade rate to malignancy of radial scars (RS) ranges widely (0%-40%) making management controversial.
Methods: A retrospective chart review was performed on patients with RS on core needle biopsy (CNB). Upgrade rates to malignancy and atypia on surgical excision were evaluated.
Results: Of 127 patients with RS on CNB, 53 were excluded due to malignancy or missing records. Of 74 patients reviewed, 52 (70.3%) had surgical excision with four (7.7%) upgraded to malignancy. Eight patients (10.8%) had atypia with RS on CNB with two (25%) upgraded to malignancy. When isolated RS was on CNB, 2 of 44 (4.5%) upgraded to malignancy while 15 of 44 (34%) had atypia on excision. Of 22 patients (29.7%) who did not have excision, zero developed cancer.
Conclusion: We found higher than expected upgrade rates of isolated RS to atypia which can alter management. Additionally, 25% of RS with atypia upgraded to malignancy suggesting these patients are at higher risk.
(© 2020 Wiley Periodicals LLC.)
Databáze: MEDLINE
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