| Autor: |
Kuchar J; Fakultät für Mathematik und Naturwissenschaften, Anorganische Chemie, Bergische Universität Wuppertal, Gaußstraße 20, 42119 Wuppertal, Germany., Rust J; Chemische Kristallographie, Max-Planck-Institut für Kohlenforschung, Kaiser-Wilhelm-Platz 1, 45470 Mülheim an der Ruhr, Germany., Lehmann CW; Chemische Kristallographie, Max-Planck-Institut für Kohlenforschung, Kaiser-Wilhelm-Platz 1, 45470 Mülheim an der Ruhr, Germany., Mohr F; Fakultät für Mathematik und Naturwissenschaften, Anorganische Chemie, Bergische Universität Wuppertal, Gaußstraße 20, 42119 Wuppertal, Germany. |
| Jazyk: |
angličtina |
| Zdroj: |
Inorganic chemistry [Inorg Chem] 2020 Aug 03; Vol. 59 (15), pp. 10557-10568. Date of Electronic Publication: 2020 Jul 13. |
| DOI: |
10.1021/acs.inorgchem.0c00982 |
| Abstrakt: |
A series of silver(I) camphorsulfonato complexes containing various phosphine ligands having the stoichiometry [Ag(camphSO 3 )(PR 3 )] [PR 3 = PTA (1,3,5-triaza-7-phosphaadamantane), PASO 2 (2-thia-1,3,5-triaza-7-phosphaadamantane-2,2-dioxide), PPh 3 , PCy 3 , P(CH 2 CH 2 CN) 3 , PPyPh 2 , or P( o -tol) 3 ] were prepared and fully characterized by NMR spectroscopic methods and X-ray crystallography. Depending on the nature of the phosphine, a variety of different supramolecular structures, including dimers, macrocycles, and coordination polymers, were observed in the solid state. The in vitro antimicrobial activity in seven different pathogens ( Staphylococcus aureus , Escherichia coli , Klebsiella pneumoniae , Pseudomonas aeruginosa , Acinetobacter baumannii , Candida albicans , and Cryptococcus neoformans var. grubii ) as well as toxicity in human cells was also examined. While all compounds show some activity against the bacteria, they were especially active against the fungus C. neoformans . The most active and at the same time least toxic compound was found to be the water-soluble complex [Ag(camphSO 3 )(PTA) 2 ]. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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