Efficacy of Phytopharmaceuticals From the Amazonian Plant Libidibia ferrea for Wound Healing in Dogs.

Autor:	Américo ÁVLDS; Laboratory of Animal Health (LARSANA), Federal University of Western Pará, Santarém, Brazil., Nunes KM; Laboratory of R&D on Pharmaceutical and Cosmetic, Federal University of Western Pará, Santarém, Brazil., de Assis FFV; Laboratory of Animal Health (LARSANA), Federal University of Western Pará, Santarém, Brazil., Dias SR; Laboratory of Animal Health (LARSANA), Federal University of Western Pará, Santarém, Brazil., Passos CTS; Laboratory of Animal Health (LARSANA), Federal University of Western Pará, Santarém, Brazil., Morini AC; Laboratory of Animal Health (LARSANA), Federal University of Western Pará, Santarém, Brazil., de Araújo JA; Laboratory of R&D on Pharmaceutical and Cosmetic, Federal University of Western Pará, Santarém, Brazil., Castro KCF; Bioactive Research and Development Laboratory, Federal University of Western Pará, Santarém, Brazil., da Silva SKR; Microbiology Laboratory, Federal University of Western Pará, Santarém, Brazil., Barata LES; Bioactive Research and Development Laboratory, Federal University of Western Pará, Santarém, Brazil., Minervino AHH; Laboratory of Animal Health (LARSANA), Federal University of Western Pará, Santarém, Brazil.
Jazyk:	angličtina
Zdroj:	Frontiers in veterinary science [Front Vet Sci] 2020 Jun 12; Vol. 7, pp. 244. Date of Electronic Publication: 2020 Jun 12 (Print Publication: 2020).
DOI:	10.3389/fvets.2020.00244
Abstrakt:	We comparatively evaluate two distinct formulations containing 5% of Jucá ( Libidibia ferrea ) for wound healing in dogs. An excision model study was performed in 11 dogs with three dermal wounds in each animal, which were treated with: (1) topical phytopharmaceutical based on Carbopol (PyC) containing 5% Jucá ethanolic extract; (2) topical phytopharmaceutical based on Astrocaryum murumuru butter (PyM) containing 5% Jucá ethanolic extract; and (3) commercial ointment (control). Wound treatment was carried out on alternated days starting at day (D) one until D21. Macroscopic (all time-points) and histological (D0 and D21) analyses were performed. The antimicrobial activity of Jucá was evaluated through Minimal Inhibitory Concentration (MIC). Phytochemical analysis of Jucá revealed 3.1% phenolic compound content expressed in rutin and the presence of hydrolyzable tannins and flavonoids. The mean wound retraction was 33.7 ± 5.5, 34.0 ± 4.7, and 28.4 ± 4.9 % for PyC, PyM, and control groups, respectively, with higher wound retraction for both herbal-treated groups compared to the control ( P < 0.05). Alcoholic extract of Jucá had antimicrobial activity against the microorganisms Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa , and Candida krusei at different degrees, with MIC ranging from 250 to 16.625 μg/ml. Microscopic evaluation showed that the phytotherapic formulations contributed to better dermal wound healing through wound fibroplasia. The alcoholic extract of Jucá pods has great potential for wound healing in dogs and can be used in the development of commercially viable phytotherapic formulations. (Copyright © 2020 Américo, Nunes, Assis, Dias, Passos, Morini, Araújo, Castro, Silva, Barata and Minervino.)
Databáze:	MEDLINE
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