The value of antimicrobial peptides in the age of resistance.

Autor:	Magana M; Department of Biopathology and Clinical Microbiology, Aeginition Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece., Pushpanathan M; Department of Human Evolutionary Biology, Harvard University, Cambridge, MA, USA., Santos AL; Department of Chemistry, Rice University, Houston, TX, USA; Investigación Sanitaria de las Islas Baleares, Palma, Spain., Leanse L; Department of Dermatology, Harvard Medical School, Boston, MA, USA; Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA, USA., Fernandez M; Department of Urologic Sciences, Vancouver Prostate Centre, University of British Columbia, Vancouver, BC, Canada., Ioannidis A; Department of Nursing, University of Peloponnese, Sparta, Greece., Giulianotti MA; Torrey Pines Institute for Molecular Studies, Port St Lucie, FL, USA., Apidianakis Y; Department of Biological Sciences, University of Cyprus, Nicosia, Cyprus., Bradfute S; Department of Internal Medicine, Center for Global Health, University of New Mexico, Albuquerque, NM, USA., Ferguson AL; Pritzker School of Molecular Engineering, University of Chicago, Chicago, IL, USA., Cherkasov A; Department of Urologic Sciences, Vancouver Prostate Centre, University of British Columbia, Vancouver, BC, Canada., Seleem MN; Department of Comparative Pathobiology, Purdue University College of Veterinary Medicine, West Lafayette, IN, USA., Pinilla C; Torrey Pines Institute for Molecular Studies, Port St Lucie, FL, USA., de la Fuente-Nunez C; Machine Biology Group, Departments of Psychiatry and Microbiology, Institute for Biomedical Informatics, Institute for Translational Medicine and Therapeutics, Perelman School of Medicine, Penn Institute for Computational Science, and Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA., Lazaridis T; Department of Chemistry, The City College of New York, New York, NY, USA; Graduate Programs in Chemistry, Biochemistry, and Physics, The Graduate Center, City University of New York, NY, USA., Dai T; Department of Dermatology, Harvard Medical School, Boston, MA, USA; Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA, USA., Houghten RA; Torrey Pines Institute for Molecular Studies, Port St Lucie, FL, USA., Hancock REW; Department of Microbiology and Immunology, Centre for Microbial Diseases and Immunity Research, University of British Columbia, Vancouver, BC, Canada., Tegos GP; Reading Hospital, Tower Health, West Reading, PA, USA; Micromoria, Venture X Marlborough, Marlborough, MA, USA. Electronic address: george.tegos@towerhealth.org.
Jazyk:	angličtina
Zdroj:	The Lancet. Infectious diseases [Lancet Infect Dis] 2020 Sep; Vol. 20 (9), pp. e216-e230. Date of Electronic Publication: 2020 Jul 09.
DOI:	10.1016/S1473-3099(20)30327-3
Abstrakt:	Accelerating growth and global expansion of antimicrobial resistance has deepened the need for discovery of novel antimicrobial agents. Antimicrobial peptides have clear advantages over conventional antibiotics which include slower emergence of resistance, broad-spectrum antibiofilm activity, and the ability to favourably modulate the host immune response. Broad bacterial susceptibility to antimicrobial peptides offers an additional tool to expand knowledge about the evolution of antimicrobial resistance. Structural and functional limitations, combined with a stricter regulatory environment, have hampered the clinical translation of antimicrobial peptides as potential therapeutic agents. Existing computational and experimental tools attempt to ease the preclinical and clinical development of antimicrobial peptides as novel therapeutics. This Review identifies the benefits, challenges, and opportunities of using antimicrobial peptides against multidrug-resistant pathogens, highlights advances in the deployment of novel promising antimicrobial peptides, and underlines the needs and priorities in designing focused development strategies taking into account the most advanced tools available. (Copyright © 2020 Elsevier Ltd. All rights reserved.)
Databáze:	MEDLINE
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