Biosurfactant electrospun nanofibers exhibit minimal side effects on the structure and function of the liver tissue in male rat model.

Autor: Ebaid HAR; Zoology Department, College of Science, King Saud University, Riyadh, 11451, Kingdom of Saudi Arabia. hossamebaid@yahoo.com.; Zoology Department, Faculty of Science, Minia University, Mina, Egypt. hossamebaid@yahoo.com., Abdel-Mageed A; Zoology Department, College of Science, King Saud University, Riyadh, 11451, Kingdom of Saudi Arabia., Al-Tamimi JH; Zoology Department, College of Science, King Saud University, Riyadh, 11451, Kingdom of Saudi Arabia., Hassan I; Zoology Department, College of Science, King Saud University, Riyadh, 11451, Kingdom of Saudi Arabia., Rady AM; Zoology Department, College of Science, King Saud University, Riyadh, 11451, Kingdom of Saudi Arabia., El-Newehy MH; Chemistry Department, College of Science, King Saud University, Riyadh, 11451, Kingdom of Saudi Arabia.; Chemistry Department, Faculty of Science, Tanta University, Tanta, 31527, Egypt., Mashaly AM; Zoology Department, Faculty of Science, Minia University, Mina, Egypt., Abdel-Megeed AAM; Faculty of Agriculture, Saba Basha, Alexandria University, Alexandria, Egypt., Alhazza I; Zoology Department, College of Science, King Saud University, Riyadh, 11451, Kingdom of Saudi Arabia., Abdel-Halim ES; Textile Research Division, National Research Center, Dokki, Cairo, Egypt., Salem AZM; Facultad de Medicina Veterinaria y Zootecnia, Universidad Autónoma del Estado de México, Toluca, Mexico. salem@uaemex.com.
Jazyk: angličtina
Zdroj: Environmental science and pollution research international [Environ Sci Pollut Res Int] 2020 Nov; Vol. 27 (32), pp. 40009-40019. Date of Electronic Publication: 2020 Jul 10.
DOI: 10.1007/s11356-020-10077-8
Abstrakt: Oil spills can result in significant damage to marine estuaries, rivers, lakes, wetlands, and shorelines. Electrospun nanofibers containing biosurfactant (ENFs) can be used to clean oil spills up and protect the environmental biology. Present work aimed to study the side-effects of prepared nanofibers on animal models. Screening of the prepared ECNFs on animals showed that three of them (PVA-5, PEO-1, and PEO-5) are safe to hepatic tissues and liver functions. Furthermore, oxidative stress did not change after using these nanofibers. The PVA-1 nanofibers, however, were found to cause major pathological changes in the liver tissue. In addition, PVA-1 nanofibers were proved to alter the total white blood count and the neutrophil percentages significantly in comparison to the control. In conclusion, PVA-5, PEO-1, and PEO-5 are safe to hepatic tissues and liver functions.
Databáze: MEDLINE