Personalized irradiation therapy for NMSC by rhenium-188 skin cancer therapy: a long-term retrospective study.

Autor: Cipriani C; Nuclear Medicine Division, AlGa Institute, Celano, Italy., Desantis M; Nuclear Medicine Division, AlGa Institute, Celano, Italy., Dahlhoff G; OncoBeta GmbH, Munich, Germany., Brown SD 3rd; OncoBeta GmbH, Munich, Germany., Wendler T; OncoBeta GmbH, Munich, Germany., Olmeda M; OncoBeta GmbH, Munich, Germany., Pietsch G; Department of Dermatology and Allergy Biederstein, School of Medicine, Technical University of Munich, Munich, Germany., Eberlein B; Department of Dermatology and Allergy Biederstein, School of Medicine, Technical University of Munich, Munich, Germany.
Jazyk: angličtina
Zdroj: The Journal of dermatological treatment [J Dermatolog Treat] 2022 Mar; Vol. 33 (2), pp. 969-975. Date of Electronic Publication: 2020 Jul 22.
DOI: 10.1080/09546634.2020.1793890
Abstrakt: Objectives: This study aimed to provide long-term clinical data about an innovative epidermal radioisotope therapy called Rhenium-SCT ® (Skin Cancer Therapy) for non-melanoma skin cancer (NMSC), based on the use of the non-sealed beta emitter rhenium-188.
Material and Methods: 52 NMSC patients with a mean age of 71.7 years were treated with rhenium-188 skin cancer therapy between the years 2005 and 2014. An acryl matrix containing rhenium-188 was applied on a plastic foil covering the tumor. The treatment time for reaching a radiation dose of 50 Gy was calculated by a software program. Patients' characteristics and clinical follow-up data were collected and retrospectively analyzed.
Results: Overall 55 lesions (32 BCC, 19 SCC, 2 M. Bowen and 2 extramammary Paget's disease (EMPD)) mainly in the head and neck region (72.3%) were treated. The average size of the irradiation area was 9.79 cm 2 and the mean treatment time 46.35 min. All lesions showed a complete remission after a follow-up period between 3 and more than 12 months. No complications or other post-interventional problems were reported.
Conclusions: Rhenium-SCT ® is considered as an effective, rapid, safe, painless treatment mostly performed in a single therapeutic session, regardless of the shape complexity, anatomical site and number of lesions.
Databáze: MEDLINE
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