| Autor: |
Rinaldi A; Department of Biology and Biotechnology C. Darwin, Sapienza University of Rome, Rome, Italy. arianna.rinaldi@uniroma1.it.; Centre for Research in Neurobiology D. Bovet, Sapienza University of Rome, Rome, Italy. arianna.rinaldi@uniroma1.it., De Leonibus E; Institute of Cellular Biology and Biochemistry, IBBC-CNR, Naples, Italy., Cifra A; Department of Biology and Biotechnology C. Darwin, Sapienza University of Rome, Rome, Italy., Torromino G; Department of Biology and Biotechnology C. Darwin, Sapienza University of Rome, Rome, Italy., Minicocci E; Department of Biology and Biotechnology C. Darwin, Sapienza University of Rome, Rome, Italy., De Sanctis E; Department of Biology and Biotechnology C. Darwin, Sapienza University of Rome, Rome, Italy., López-Pedrajas RM; Department of Biology and Biotechnology C. Darwin, Sapienza University of Rome, Rome, Italy.; Departamento de Ciencias Biomédicas, Universidad Cardenal Herrera-CEU, CEU Universities, Valencia, Spain., Oliverio A; Department of Biology and Biotechnology C. Darwin, Sapienza University of Rome, Rome, Italy.; Centre for Research in Neurobiology D. Bovet, Sapienza University of Rome, Rome, Italy., Mele A; Department of Biology and Biotechnology C. Darwin, Sapienza University of Rome, Rome, Italy.; Centre for Research in Neurobiology D. Bovet, Sapienza University of Rome, Rome, Italy. |
| Abstrakt: |
Goal-directed navigation can be based on world-centered (allocentric) or body-centered (egocentric) representations of the environment, mediated by a wide network of interconnected brain regions, including hippocampus, striatum and prefrontal cortex. The relative contribution of these regions to navigation from novel or familiar routes, that demand a different degree of flexibility in the use of the stored spatial representations, has not been completely explored. To address this issue, we trained mice to find a reward relying on allocentric or egocentric information, in a modified version of the cross-maze task. Then we used Zif268 expression to map brain activation when well-trained mice were required to find the goal from a novel or familiar location. Successful navigation was correlated with the activation of CA1, posterior-dorsomedial striatum, nucleus accumbens core and infralimbic cortex when allocentric-trained mice needed to use a novel route. Allocentric navigation from a familiar route activated dorsomedial striatum, nucleus accumbens, prelimbic and infralimbic cortex. None of the structures analyzed was significantly activated in egocentric-trained mice, irrespective of the starting position. These data suggest that a flexible use of stored allocentric information, that allows goal finding even from a location never explored during training, induces a shift from fronto-striatal to hippocampal circuits. |
