Inhibitory Properties of Aldehydes and Related Compounds against Phytophthora infestans -Identification of a New Lead.

Autor: Mackrill JJ; Department of Physiology, School of Medicine, University College Cork, T12 K8AF Cork, Ireland., Kehoe RA; School of Chemistry and Analytical and Biological Chemistry Research Facility, University College Cork, Western Road, T12 K8AF Cork, Ireland., Zheng L; Department of Physiology, School of Medicine, University College Cork, T12 K8AF Cork, Ireland., McKee ML; School of Chemistry and Analytical and Biological Chemistry Research Facility, University College Cork, Western Road, T12 K8AF Cork, Ireland., O'Sullivan EC; School of Chemistry and Analytical and Biological Chemistry Research Facility, University College Cork, Western Road, T12 K8AF Cork, Ireland., Prestwich BMD; School of Biological, Earth and Environmental Sciences, University College Cork, T12 K8AF Cork, Ireland., McCarthy FO; School of Chemistry and Analytical and Biological Chemistry Research Facility, University College Cork, Western Road, T12 K8AF Cork, Ireland.
Jazyk: angličtina
Zdroj: Pathogens (Basel, Switzerland) [Pathogens] 2020 Jul 07; Vol. 9 (7). Date of Electronic Publication: 2020 Jul 07.
DOI: 10.3390/pathogens9070542
Abstrakt: The pathogen Phytophthora infestans is responsible for catastrophic crop damage on a global scale which totals billions of euros annually. The discovery of new inhibitors of this organism is of paramount agricultural importance and of critical relevance to food security. Current strategies for crop treatment are inadequate with the emergence of resistant strains and problematic toxicity. Natural products such as cinnamaldehyde have been reported to have fungicidal properties and are the seed for many new discovery research programmes. We report a probe of the cinnamaldehyde framework to investigate the aldehyde subunit and its role in a subset of aromatic aldehydes in order to identify new lead compounds to act against P. infestans . An ellipticine derivative which incorporates an aldehyde (9-formyl-6-methyl ellipticine, 34 ) has been identified with exceptional activity versus P. infestans with limited toxicity and potential for use as a fungicide.
Databáze: MEDLINE
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