Kernicterus
| Autor: | Reddy DK; Rajiv Gandhi University, Pandey S; LSU-HSC / Monroe Family Medicine Program |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | 2021 Jan. |
| Abstrakt: | Kernicterus, or bilirubin encephalopathy, is bilirubin-induced neurological damage, which is most commonly seen in infants. It occurs when the unconjugated bilirubin (indirect bilirubin) levels cross 25 mg/dL in the blood from any event leading to decreased elimination and increased production of bilirubin. The unconjugated bilirubin can cross the blood-brain barrier as it is lipid-soluble, unlike the water-soluble conjugated bilirubin. It gets deposited in the brain tissue, mainly the basal ganglia. The neurotoxicity of unconjugated bilirubin leads to various neurologic sequelae.[1] (Copyright © 2021, StatPearls Publishing LLC.) |
| Databáze: | MEDLINE |
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