On the potential role of exosomes in the COVID-19 reinfection/reactivation opportunity.
| Autor: | Elrashdy F; Department of Endemic Medicine and Hepatogastroenterology, Kasr Alainy School of Medicine, Cairo University, Cairo, Egypt., Aljaddawi AA; Biological Science Department, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia., Redwan EM; Biological Science Department, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia., Uversky VN; Biological Science Department, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.; Department of Molecular Medicine and USF Health Byrd Alzheimer's Research Institute, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.; Institute for Biological Instrumentation of the Russian Academy of Sciences, Federal Research Center 'Pushchino Scientific Center for Biological Research of the Russian Academy of Sciences', Pushchino, Russia. |
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| Jazyk: | angličtina |
| Zdroj: | Journal of biomolecular structure & dynamics [J Biomol Struct Dyn] 2021 Sep; Vol. 39 (15), pp. 5831-5842. Date of Electronic Publication: 2020 Jul 09. |
| DOI: | 10.1080/07391102.2020.1790426 |
| Abstrakt: | We propose here that one of the potential mechanisms for the relapse of the COVID-19 infection could be a cellular transport pathway associated with the release of the SARS-CoV-2-loaded exosomes and other extracellular vesicles. It is possible that this "Trojan horse" strategy represents possible explanation for the re-appearance of the viral RNA in the recovered COVID-19 patients 7-14 day post discharge, suggesting that viral material was hidden within such exosomes or extracellular vesicles during this "silence" time period and then started to re-spread again.Communicated by Ramaswamy H. Sarma. |
| Databáze: | MEDLINE |
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