Investigation of Human Cytomegalovirus and Human Papillomavirus in Glioma.

Autor: Limam S; Pathology Department, Farhet Hached University Hospital, Sousse, Tunisia., Missaoui N; Research Unit UR14ES17, Medicine Faculty, Sousse University, Sousse, Tunisia.; Faculty of Sciences and Techniques of Sidi Bouzid, Kairouan University, Kairouan, Tunisia.; Pathology Department, Sahloul University Hospital, Sousse, Tunisia., Hmissa S; Pathology Department, Sahloul University Hospital, Sousse, Tunisia., Yacoubi MT; Pathology Department, Farhet Hached University Hospital, Sousse, Tunisia., Krifa H; Department of Neurosurgery, Sahloul University Hospital, Sousse, Tunisia., Mokni M; Pathology Department, Farhet Hached University Hospital, Sousse, Tunisia., Selmi B; Higher Institute of Biotechnology, Monastir University, Monastir, Tunisia.
Jazyk: angličtina
Zdroj: Cancer investigation [Cancer Invest] 2020 Aug; Vol. 38 (7), pp. 394-405. Date of Electronic Publication: 2020 Jul 27.
DOI: 10.1080/07357907.2020.1793352
Abstrakt: The study investigated the human cytomegalovirus (HCMV) and human papillomavirus (HPV) in gliomas. A retrospective study was conducted on 112 samples. HCMV was investigated by PCR, in situ hybridization (ISH) and immunohistochemistry. HPV was tested by PCR and DNA ISH. HCMV was identified in 60 gliomas, including 55 GBM. However, RNA ISH and immunohistochemistry failed to detect HCMV positivity. HPV was identified in 44 GBM. No significant relationship was identified between HCMV and HPV and tumour characteristics ( p  > 0.05). Our findings support the HCMV and HPV presence in gliomas. Further assays are required to more explore the potential efficient antiviral management.
Databáze: MEDLINE
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