High levels of KLK7 protein expression are related to a favorable prognosis in triple-negative breast cancer patients.

Autor:	Geng X; Clinical Research Unit, Department of Obstetrics and Gynecology, Technical University of Munich (TUM) Germany., Babayeva L; Clinical Research Unit, Department of Obstetrics and Gynecology, Technical University of Munich (TUM) Germany., Walch A; Research Unit Analytical Pathology, Helmholtz Zentrum München Neuherberg, Germany., Aubele M; Institute of Pathology, Helmholtz Zentrum München Neuherberg, Germany., Groß E; Department of Obstetrics and Gynecology, University of Munich (LMU) Germany., Kiechle M; Clinical Research Unit, Department of Obstetrics and Gynecology, Technical University of Munich (TUM) Germany., Bronger H; Clinical Research Unit, Department of Obstetrics and Gynecology, Technical University of Munich (TUM) Germany., Dreyer T; Clinical Research Unit, Department of Obstetrics and Gynecology, Technical University of Munich (TUM) Germany., Magdolen V; Clinical Research Unit, Department of Obstetrics and Gynecology, Technical University of Munich (TUM) Germany., Dorn J; Clinical Research Unit, Department of Obstetrics and Gynecology, Technical University of Munich (TUM) Germany.
Jazyk:	angličtina
Zdroj:	American journal of cancer research [Am J Cancer Res] 2020 Jun 01; Vol. 10 (6), pp. 1785-1792. Date of Electronic Publication: 2020 Jun 01 (Print Publication: 2020).
Abstrakt:	In normal physiology, kallikrein-related peptidase 7 (KLK7), together with other members of the kallikrein-related peptidase family, is mainly involved in skin desquamation and keratinization processes. Moreover, expression of KLK7 was shown in various tumor types to be dysregulated and to correlate to patients' survival time. However, there are contradictory reports in breast cancer whether KLK7 represents an unfavorable or favorable prognostic biomarker. In the present study, we examined the prognostic value of KLK7 protein expression in triple-negative breast cancer (TNBC), determined by immunohistochemistry (IHC). A cohort encompassing 133 TNBC specimens, present on tissue microarrays, was analyzed. For quantification of the staining intensity, an automated digital IHC image analysis algorithm was applied. In both Kaplan-Meier and univariate Cox analyses, elevated KLK7 protein levels were significantly linked with prolonged overall survival (OS). In multivariable Cox analysis, addition of KLK7 immunoreactivity scores to the base model (including the clinical parameters age, tumor size, and nodal status) demonstrated that KLK7 protein expression remained as a statistically significant, independent parameter for prolonged OS. These results strongly indicate that KLK7 is a favorable prognostic biomarker in triple-negative breast cancer. Competing Interests: None. (AJCR Copyright © 2020.)
Databáze:	MEDLINE
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