Microtomographic analysis of the effect of sodium alendronate on orthodontic movement in rats.

Autor: Lopes LLA; Department of Dentistry, Christus University Center, Fortaleza, Brazil., de Barros Silva PG; Department of Dentistry, Christus University Center, Fortaleza, Brazil., Damasceno JX; Department of Dentistry, Christus University Center, Fortaleza, Brazil., Martins JOL; Department of Dentistry, Christus University Center, Fortaleza, Brazil., da Silva KR; Postgraduate Program in Dentistry, Health Sciences Center, Federal University of Paraíba, João Pessoa, Brazil., de Sousa FB; Postgraduate Program in Dentistry, Health Sciences Center, Federal University of Paraíba, João Pessoa, Brazil., Dantas HV; Postgraduate Program in Dentistry, Health Sciences Center, Federal University of Paraíba, João Pessoa, Brazil., Ribeiro TR; Department of Dentistry, Ceará Federal University, Fortaleza, Brazil., Alencar PNB; Department of Dentistry, Christus University Center, Fortaleza, Brazil.
Jazyk: angličtina
Zdroj: Orthodontics & craniofacial research [Orthod Craniofac Res] 2021 Feb; Vol. 24 (1), pp. 96-101. Date of Electronic Publication: 2020 Jul 24.
DOI: 10.1111/ocr.12410
Abstrakt: Objective: To evaluate the effect of sodium alendronate on orthodontic tooth movement in rats using microtomographic analysis.
Settings and Sample Population: Thirty male Wistar rats (Rattus norvegicus) were divided into three groups of 10 rats and administered saline (control), 1 mg/kg sodium alendronate or 6 mg/kg sodium alendronate, respectively.
Materials and Methods: The drug was administered once per week for 5 weeks by gavage. Orthodontic movement was induced during the last 2 weeks of medication administration by inserting a closed nickel-titanium spring between the left upper first molar and central incisors. The opposite side served as the control. Tooth movement and bone trabeculation in the furcation region were evaluated by microtomographic analysis in the first (moved) and third (static) molars. The data were subjected to one-way or two-way ANOVA and Bonferroni test (P < .05).
Results: The microtomographic images of the group that received 6 mg/kg sodium alendronate demonstrated significantly less tooth movement (P = .048), less space between the trabeculae (P = .031) and greater number of bone trabeculae (P = .033) compared to the other groups. There were no statistically significant differences in bone volume and mean trabecular thickness between the three groups. The static teeth did not show the same alterations (P > .05).
Conclusion: Sodium alendronate treatment reduced tooth movement in rats.
(© 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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