MRI Measurement of Upper Cervical Spinal Cord Cross-Sectional Area in Children.

Autor: Papinutto N; UCSF Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco, CA., Cordano C; UCSF Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco, CA., Asteggiano C; UCSF Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco, CA.; Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy., Caverzasi E; UCSF Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco, CA., Mandelli ML; UCSF Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco, CA., Lauricella M; UCSF Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco, CA., Yabut N; UCSF Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco, CA., Neylan M; UCSF Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco, CA., Kirkish G; UCSF Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco, CA., Gorno-Tempini ML; UCSF Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco, CA., Henry RG; UCSF Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco, CA.
Jazyk: angličtina
Zdroj: Journal of neuroimaging : official journal of the American Society of Neuroimaging [J Neuroimaging] 2020 Sep; Vol. 30 (5), pp. 598-602. Date of Electronic Publication: 2020 Jul 08.
DOI: 10.1111/jon.12758
Abstrakt: Background and Purpose: Neurological and neurodegenerative diseases can affect the spinal cord (SC) of pediatric patients. Magnetic resonance imaging (MRI) allows for in vivo quantification of SC atrophy via cross-sectional area (CSA). The study of CSA values in the general population is important to disentangle disease-related changes from intersubject variability. This study aimed at providing normative values for cervical CSA in children, extending our previous work performed with adults.
Methods: Seventy-eight children (age 7-17 years) were selected from a Developmental Dyslexia study. All subjects underwent a 3T brain MRI session and any incidental findings were reported on the scans. A sagittal 1 mm 3 3-dimensional T 1 -weighted brain acquisition extended to the upper cervical cord was used to measure CSA at C2-C3, as well as spinal canal area and skull volume (V-scale). These three metrics were linearly fitted as a function of age to extract trends and percentage annual changes. Sex differences of CSA were assessed using least squares regression analyses, adjusting for age. We tested normalization strategies proven to be effective in reducing the intersubject variability of adults' CSA.
Results: CSA changed as a function of age at a faster rate when compared with skull volume (CSA: 1.82% increase, V-scale: .60% reduction). Sex had a statistically significant effect on CSA. Normalization methods based on canal area and skull volume reduced the CSA intersubject variability up to 16.84%.
Conclusions: We present CSA normative values in a large cohort of children, reporting on sources of intersubject variability and how to reduce them applying normalization methods previously developed.
(© 2020 American Society of Neuroimaging.)
Databáze: MEDLINE
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