Exploring the role of microRNAs in axolotl regeneration.

Autor: Abo-Al-Ela HG; Department of Aquaculture, Faculty of Fish Resources, Suez University, Suez, Egypt., Burgos-Aceves MA; Department of Chemistry and Biology, University of Salerno, Fisciano, Salerno, Italy.
Jazyk: angličtina
Zdroj: Journal of cellular physiology [J Cell Physiol] 2021 Feb; Vol. 236 (2), pp. 839-850. Date of Electronic Publication: 2020 Jul 07.
DOI: 10.1002/jcp.29920
Abstrakt: The axolotl, Ambystoma mexicanum, is used extensively for research in developmental biology, particularly for its ability to regenerate and restore lost organs, including in the nervous system, to full functionality. Regeneration in mammals typically depends on the healing process and scar formation with limited replacement of lost tissue. Other organisms, such as spiny mice (Acomys cahirinus), salamanders, and zebrafish, are able to regenerate some damaged body components. Blastema is a tissue that is formed after tissue injury in such organisms and is composed of progenitor cells or dedifferentiated cells that differentiate into various cell types during regeneration. Thus, identifying the molecules responsible for initiation of blastema formation is an important aspect for understanding regeneration. Introns, a major source of noncoding RNAs (ncRNAs), have characteristic sizes in the axolotl, particularly in genes associated with development. These ncRNAs, particularly microRNAs (miRNAs), exhibit dynamic regulation during regeneration. These miRNAs play an essential role in timing and control of gene expression to order and organize processes necessary for blastema creation. Master keys or molecules that underlie the remarkable regenerative abilities of the axolotl remain to be fully explored and exploited. Further and ongoing research on regeneration promises new knowledge that may allow improved repair and renewal of human tissues.
(© 2020 Wiley Periodicals LLC.)
Databáze: MEDLINE
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