| Autor: |
Moghiman T; Atherosclerosis Prevention Research Center, Mashhad University of Medical Sciences, Mashhad, Iran., Barghchi B; Medical School, Islamic Azad University, Tehran Branch, Tehran, Iran., Esmaeili SA; Immunology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.; Immunology Department, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran., Shabestari MM; Interventional Cardiology, Atherosclerosis Prevention Research Center, Mashhad University of Medical Sciences, Mashhad, Iran., Tabaee SS; Cardiology Noncommunicable Disease Research Center, Neyshabur University of Medical Sciences, Neyshabur, Iran. tabaees79@yahoo.com., Momtazi-Borojeni AA; Halal Research center of IRI, FDA, Tehran, Iran. abbasmomtazi@yahoo.com.; Department of Medical Biotechnology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. abbasmomtazi@yahoo.com. |
| Jazyk: |
angličtina |
| Zdroj: |
Heart failure reviews [Heart Fail Rev] 2021 Jan; Vol. 26 (1), pp. 205-213. |
| DOI: |
10.1007/s10741-020-10001-9 |
| Abstrakt: |
Therapeutic angiogenesis presents a potential approach for treating ischemic heart diseases especially in patients who are not appropriate candidates for traditional approaches of revascularization. This approach acts through inducing the neovascularization or maturation of pre-existing collateral vessels into functional arteries to bypass the blocked arteries and restore perfusion to ischemic myocardium. Successful stimulation of local angiogenesis can be established by the cross talk between stem cells, endothelial cells, and cardiomyocytes, which is mainly mediated by paracrine communication accompanied by secreted exosomes. Exosomes are extracellular vesicles carrying a complex of signaling molecules, such as microRNAs (miRs) that can modulate the function of recipient cells. Such particles have been indicated to exert cardioprotective role through providing signaling cues for angiogenesis, an effect ascribed mainly to their miRs content. Exosomal miRs-mediated therapeutic angiogenesis has been under drastic preclinical and clinical studies. In the current review, it was aimed to summarize pro-angiogenic exosomal miRs released by various cell types mediating angiogenesis, including stem cells, endothelial cells, and cardiomyocytes, which appear to exert a therapeutic effect on the myocardial ischemia. In brief, secreted exosomal miRs including miR-210, miR-23a-3p, miR-424, let-7f, miR-30b, miR-30c, miR-126, miR-21, miR-132, miR-130a-3p, miR-214, miR-378, miR-126, miR-133, and let-7b-5p could protect against myocardial ischemia through inducing cardiac angiogenesis and vascular regeneration resulting in the increase blood flow to ischemic myocardium. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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