Thickness of Intraretinal Layers in Patients with Type 2 Diabetes Mellitus Depending on a Concomitant Diabetic Neuropathy: Results of a Cross-Sectional Study Using Deviation Maps for OCT Data Analysis.

Autor:	Prakasam RK; Department of Ophthalmology, University Medical Center Rostock, Doberaner Str. 140, 18057 Rostock, Germany.; Professor Brien Holden Eye Research Centre, L V Prasad Eye Institute, Road 2 Banjara Hills, Hyderabad 500034, India., Matuszewska-Iwanicka A; Ruhr University Bochum, Johannes Wesling Hospital Minden, Hans-Nolte-Straße 1, 32429 Minden, Germany., Fischer DC; Department of Pediatrics, University Medical Center Rostock, Ernst-Heydemann-Str. 8, 18057 Rostock, Germany., Schumann H; Institute of Visual and Analytic Computing, University of Rostock, Albert-Einstein-Straße 22, 18059 Rostock, Germany., Tschöpe D; Heart and Diabetes Center NRW, Ruhr University Bochum, Georgstraße 11, 32545 Bad Oeynhausen, Germany., Stratmann B; Heart and Diabetes Center NRW, Ruhr University Bochum, Georgstraße 11, 32545 Bad Oeynhausen, Germany., Hettlich HJ; Ruhr University Bochum, Johannes Wesling Hospital Minden, Hans-Nolte-Straße 1, 32429 Minden, Germany., Guthoff RF; Department of Ophthalmology, University Medical Center Rostock, Doberaner Str. 140, 18057 Rostock, Germany., Stachs O; Department of Ophthalmology, University Medical Center Rostock, Doberaner Str. 140, 18057 Rostock, Germany., Röhlig M; Institute of Visual and Analytic Computing, University of Rostock, Albert-Einstein-Straße 22, 18059 Rostock, Germany.
Jazyk:	angličtina
Zdroj:	Biomedicines [Biomedicines] 2020 Jul 02; Vol. 8 (7). Date of Electronic Publication: 2020 Jul 02.
DOI:	10.3390/biomedicines8070190
Abstrakt:	Optical coherence tomography (OCT) supports the detection of thickness changes in intraretinal layers at an early stage of diabetes mellitus. However, the analysis of OCT data in cross-sectional studies is complex and time-consuming. We introduce an enhanced deviation map-based analysis (MA) and demonstrate its effectiveness in detecting early changes in intraretinal layer thickness in adults with type 2 diabetes mellitus (T2DM) compared to common early treatment diabetic retinopathy study (ETDRS) grid-based analysis (GA). To this end, we obtained OCT scans of unilateral eyes from 33 T2DM patients without diabetic retinopathy and 40 healthy controls. The patients were categorized according to concomitant diabetic peripheral neuropathy (DN). The results of MA and GA demonstrated statistically significant differences in retinal thickness between patients and controls. Thinning was most pronounced in total retinal thickness and the thickness of the inner retinal layers in areas of the inner macular ring, selectively extending into areas of the outer macular ring and foveal center. Patients with clinically proven DN showed the strongest thinning of the inner retinal layers. MA showed additional areas of thinning whereas GA tended to underestimate thickness changes, especially in areas with localized thinning. We conclude that MA enables a precise analysis of retinal thickness data and contributes to the understanding of localized changes in intraretinal layers in adults with T2DM.
Databáze:	MEDLINE
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