[The use of retinoids to stimulate the regenerative process in trepanation cavity after "open" sanitizing surgery on the middle ear].
| Autor: | Semenov FV; Kuban State Medical University of the Ministry of Health of Russia, Krasnodar, Russia., Leonov GK; Kuban State Medical University of the Ministry of Health of Russia, Krasnodar, Russia. |
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| Jazyk: | ruština |
| Zdroj: | Vestnik otorinolaringologii [Vestn Otorinolaringol] 2020; Vol. 85 (3), pp. 28-31. |
| DOI: | 10.17116/otorino20208503128 |
| Abstrakt: | Introduction: One of the methods of surgical treatment of patients with chronic purulent otitis media is an "open" sanitizing surgery on the middle ear. One of its important features is the formation of a wound surface that communicates with the external environment, which subsequently leads to infection, lengthening the time for epithelization, and in 13-30% of cases, the latter is incomplete with the development of a "trepanation cavity disease". Objective: To establish the nature of the effect of retinoid-based drugs on the severity of the inflammatory process and the regeneration processes in the tissues of the trepanation cavity after sanitizing operations on the middle ear. Material and Methods: The subjects of the study were 78 patients who underwent the first "open" sanitizing operation on the middle ear. At the final stage, turunda with a 1% dioxin solution in combination with a sterile ointment of 13-cis-retinoic acid, concentration 0.05% was injected into the postsurgery cavity. 30 patients additionally took 13-cis-retinoic acid in tablet form. In the control group, retinoids were not used. Conclusion: The obtained data allow us to recommend the use of retinoid-based drugs as a means of suppressing the inflammatory reaction and stimulating the regeneration process in the trepanation cavity after an "open" sanitizing surgery on the middle ear. |
| Databáze: | MEDLINE |
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