Expression of tissue factor mRNA in thrombosis associated with antiphospholipid syndrome.

Autor: Mazetto BM; Faculty of Medical Sciences, University of Campinas, Campinas, Brazil., Lazarini M; Hematology and Hemotherapy Center, University of Campinas, Campinas, Brazil., Tobaldini LQ; Faculty of Medical Sciences, University of Campinas, Campinas, Brazil.; Hematology and Hemotherapy Center, University of Campinas, Campinas, Brazil., Arantes FT; Faculty of Medical Sciences, University of Campinas, Campinas, Brazil.; Hematology and Hemotherapy Center, University of Campinas, Campinas, Brazil., Dos Santos APR; Faculty of Medical Sciences, University of Campinas, Campinas, Brazil.; Hematology and Hemotherapy Center, University of Campinas, Campinas, Brazil., Jacinto BC; Faculty of Medical Sciences, University of Campinas, Campinas, Brazil.; Hematology and Hemotherapy Center, University of Campinas, Campinas, Brazil., Vaz CO; Faculty of Medical Sciences, University of Campinas, Campinas, Brazil.; Hematology and Hemotherapy Center, University of Campinas, Campinas, Brazil., Mesquita GTV; Faculty of Medical Sciences, University of Campinas, Campinas, Brazil.; Hematology and Hemotherapy Center, University of Campinas, Campinas, Brazil., Saraiva SDS; Faculty of Medical Sciences, University of Campinas, Campinas, Brazil.; Hematology and Hemotherapy Center, University of Campinas, Campinas, Brazil., Annichino-Bizzacchi J; Hematology and Hemotherapy Center, University of Campinas, Campinas, Brazil.; Department of Clinical Medicine, University of Campinas, Campinas, Brazil., Orsi FA; Hematology and Hemotherapy Center, University of Campinas, Campinas, Brazil. ferorsi@unicamp.br.; Department of Clinical Pathology, Faculty of Medical Sciences, University of Campinas, Campinas R. Tessália Vieira de Camargo, 126, Cidade Universitária Zeferino Vaz, Campinas, 13083-887, Brazil. ferorsi@unicamp.br.
Jazyk: angličtina
Zdroj: Journal of thrombosis and thrombolysis [J Thromb Thrombolysis] 2021 Feb; Vol. 51 (2), pp. 370-378.
DOI: 10.1007/s11239-020-02209-1
Abstrakt: Tissue factor (TF) is a procoagulant protein associated with increased risk of thrombotic events in antiphospholipid syndrome (t-APS). The mechanisms by which TF levels are increased in APS have not yet been established. The aim of this study was to investigate whether TF mRNA expression is associated with TF levels and thrombosis in APS. We compared levels of circulating TF and high sensitivity C-reactive protein (hs-CRP) between t-APS and controls (individuals without thrombosis). The association between TF mRNA expression, quantified by real time quantitative polymerase chain reaction, and t-APS was accessed using regression analysis. We included 41 controls and 42 t-APS patients, mean age was 41 years old (SD 14) in both groups. Hs-CRP and TF levels were higher in t-APS patients (mean hs-CRP levels 0.81 mg/dL [SD 1.88] and median TF levels 249.0 pg/mL [IQR 138.77-447.61]) as compared to controls (mean hs-CRP levels 0.24 mg/dL [SD 0.26] and median TF levels 113.0 pg/mL [IQR 81.17-161.53]; P = 0.02 and P < 0.0001, respectively). There was no correlation between TF mRNA expression and TF levels in t-APS (r - 0.209, P = 0.19). TF mRNA expression was not associated with t-APS (adjusted OR 1.16; 95%CI 0.72-1.87). Despite circulating TF levels being higher in patients with t-APS than in controls, TF mRNA expression was similar between groups. The results demonstrate that TF mRNA expression is not associated with levels of circulating TF and hypercoagulability in t-APS.
Databáze: MEDLINE
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