Facial rejuvenation using stem cell conditioned media combined with skin needling: A split-face comparative study.

Autor: El-Domyati M; Department of Dermatology, STD's and Andrology, Faculty of Medicine, Minia University, Al Minya, Egypt., Moftah NH; Department of Dermatology, STD's and Andrology, Faculty of Medicine, Minia University, Al Minya, Egypt., Nasif GA; Department of Dermatology, STD's and Andrology, Faculty of Medicine, Minia University, Al Minya, Egypt., Ameen SW; Department of Dermatology, STD's and Andrology, Faculty of Medicine, Minia University, Al Minya, Egypt., Ibrahim MR; Department of Dermatology, STD's and Andrology, Faculty of Medicine, Minia University, Al Minya, Egypt., Ragaie MH; Department of Dermatology, STD's and Andrology, Faculty of Medicine, Minia University, Al Minya, Egypt.
Jazyk: angličtina
Zdroj: Journal of cosmetic dermatology [J Cosmet Dermatol] 2020 Sep; Vol. 19 (9), pp. 2404-2410. Date of Electronic Publication: 2020 Jul 21.
DOI: 10.1111/jocd.13594
Abstrakt: Background: The use of stem cells derived growth factors is representing a novel treatment modality in facial rejuvenation. Nowadays, skin needling is considered a very famous treatment of skin aging. However, the addition of such derived products, augments its therapeutic efficacy in the management and delay of skin aging.
Objective: Comparing the effect of amniotic fluid mesenchymal stem cell derived conditioned media (AF-MSC-CM) combined with skin needling versus the needling alone in the management of facial aging.
Methods: Both sides of the face of ten volunteers, suffering from facial aging, were treated with five sessions of skin needling, 2 weeks apart. After skin microneedling, AF-MSC-CM was added topically to the right side only. Clinical, histological, and morphometrical assessment of the treated skin was done at 1 month after the last session.
Results: The percentage of improvement of aged skin increased significantly on the combined treated side (AF-MSC-CM and dermaroller [DR]), when compared with the other side (DR only) (P < .001). Remodeling of the dermal structures was observed mainly on the combined side. Meanwhile, histometry of the epidermis revealed a significant increase in the epidermal thickness on both treated sides.
Conclusion: AF-MSC-CM combined with skin needling was more efficient in managing facial aging than skin needling alone.
(© 2020 Wiley Periodicals LLC.)
Databáze: MEDLINE
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